Modeling cerebral blood flow and ventilation instability due to CO2-Reference-Cited by-同舟云学术

Modeling cerebral blood flow and ventilation instability due to CO2

Published:2021-05-01 Issue:5 Volume:130 Page:1427-1435
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Yamashiro Stanley M.¹,Kato Takahide²

Affiliation:

1. Biomedical Engineering Department, University of Southern California, Los Angeles, California;

2. Department of General Education, National Institute of Technology, Toyota College, Toyota, Japan

Abstract

Prior models of brain blood flow and respiratory control have not focused on instability. Time varying time delay resulting from brain blood flow changes due to carbon dioxide (CO2) and peripheral chemoreceptor gain were predicted to be important determinants of instability due to nonlinear interaction in addition to linear control loop gain. Time delay was assumed to be set by the ratio of brain arterial vascular volume and blood flow. This vascular volume was predicted to also significantly change with CO2.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00949.2020

Reference20 articles.

1. Mathematical analysis and digital simulation of the respiratory control system.

2. A Mathematical Model of the Human Respiratory Control System

3. Central and peripheral chemoreflex loop gain in normal and carotid body-resected subjects

4. Using Loop Gain to Assess Ventilatory Control in Obstructive Sleep Apnea

5. Breath-holding as a means to estimate the loop gain contribution to obstructive sleep apnoea

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Infant periodic breathing and apneic threshold;Physiological Reports;2024-01

2. Cerebral blood flow, cerebrovascular reactivity and their influence on ventilatory sensitivity;Experimental Physiology;2021-05-20