Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort-Reference-Cited by-同舟云学术

Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort

Published:2024-06-01 Issue:6 Volume:136 Page:1516-1525
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Nokes Brandon¹²^ORCID,Orr Jeremy E.²^ORCID,White Stephanie²,Luu Steven²,Chen Zihan²,Alex Raichel³,Sands Scott A.³,Wojeck Brian S.⁴,Owens Robert L.²^ORCID,Malhotra Atul²,Schmickl Christopher N.²

Affiliation:

1. Sleep Medicine Section, Veterans Affairs San Diego Healthcare System, San Diego, California, United States

2. Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, California, United States

3. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States

4. Section of Endocrinology, Yale School of Medicine, New Haven, Connecticut, United States

Abstract

Our data provide important insights into obesity-related obstructive sleep apnea (OSA) pathogenesis, thereby validating, and extending, prior research findings. This is the largest sample size study to examine the relationships between obesity and gender on OSA pathogenesis. The influence of obesity on sleep apnea severity is mediated by different mechanistic traits (endotypes).

Funder

American Academy of Sleep Medicine Foundation

American Heart Association

HHS | NIH | Division of Loan Repayment

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00925.2023

Reference51 articles.