Icing after eccentric contraction-induced muscle damage perturbs the disappearance of necrotic muscle fibers and phenotypic dynamics of macrophages in mice

Author:

Kawashima Masato1,Kawanishi Noriaki2,Tominaga Takaki34,Suzuki Katsuhiko5,Miyazaki Anna1,Nagata Itsuki6,Miyoshi Makoto7,Miyakawa Motoi8,Sakuraya Tohma1,Sonomura Takahiro9,Arakawa Takamitsu1ORCID

Affiliation:

1. Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences, Kobe, Japan

2. Faculty of Advanced Engineering, Chiba Institute of Technology, Narashino, Japan

3. Graduate School of Sport Sciences, Waseda University, Tokorozawa, Japan

4. Research Fellow of Japan Society for the Promotion of Sciences, Tokyo, Japan

5. Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan

6. Faculty of Health Sciences, Kobe University School of Medicine, Kobe, Japan

7. Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan

8. Department of Health and Sport Sciences, Graduate school of Medicine, Osaka University, Osaka, Japan

9. Department of Oral Anatomy, Asahi University School of Dentistry, Gifu, Japan

Abstract

Icing blunted the muscle regeneration by perturbing the infiltration of polynuclear and mononuclear cells into necrotic myofibers and the phenotypic dynamics of macrophages rather than affecting the myogenic regulatory factors. Because of icing, the disappearance of necrotic muscle debris was retarded, coinciding with the delayed emergence and sustained accumulation of Pax7+ cells within the regenerating area. The expression patterns of TNF-α and IL-10 were altered by icing consistent with the perturbation of the macrophage phenotype.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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