Biomarkers to measure respiratory muscle damage following inspiratory pressure threshold loading in healthy young men

Author:

Iqbal Muneeb123ORCID,Bliss Edward1234ORCID,Whiteside Eliza134,Hoffman Ben1ORCID,Mills Dean E.123

Affiliation:

1. School of Health and Medical Sciences, University of Southern Queensland, Ipswich, Queensland, Australia

2. Respiratory and Exercise Physiology Research Group, School of Health and Medical Sciences, University of Southern Queensland, Ipswich, Queensland, Australia

3. Centre for Health Research, Institute for Resilient Regions, University of Southern Queensland, Ipswich, Queensland, Australia

4. Molecular Biomarkers Research Group, University of Southern Queensland, Toowoomba, Queensland, Australia

Abstract

We investigated inspiratory pressure threshold loading-induced respiratory muscle damage using a skeletal muscle damage biomarkers panel. Our investigation showed that creatine kinase muscle-type, and fast skeletal troponin I could be used to assess respiratory muscle damage immediately (1 h), whereas creatine kinase muscle-type, and slow skeletal troponin I could be used to assess respiratory muscle damage 24 and 48 h following conditions that cause elevated inspiratory muscle work.

Funder

University of Southern Queensland

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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