A model of anemic tissue perfusion after blood transfusion shows critical role of endothelial response to shear stress stimuli-Reference-Cited by-同舟云学术

A model of anemic tissue perfusion after blood transfusion shows critical role of endothelial response to shear stress stimuli

Published:2021-12-01 Issue:6 Volume:131 Page:1815-1823
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Li Weiyu¹,Tsai Amy G.²,Intaglietta Marcos²,Tartakovsky Daniel M.¹^ORCID

Affiliation:

1. Department of Energy Resources Engineering, Stanford University, Stanford, California

2. Department of Bioengineering, University of California, San Diego, California

Abstract

Transfusion of 1 or 2 units of blood accounts for about 3/4 of the world blood consumption of 119 million units per year, whereas a current world demand deficit is on the order of 100 million units. Therefore, factors supporting the practice of transfusing 1 unit instead of 2 are of interest, given their potential to expand the number of interventions without increasing blood availability. Our mathematical model provides a physiological support for this practice.

Funder

DOD | USAF | AFMC | Air Force Office of Scientific Research

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00524.2021

Reference33 articles.

1. Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity

2. Paradoxical hypotension following increased hematocrit and blood viscosity

3. The Effect of Small Changes in Hematocrit on Nitric Oxide Transport in Arterioles

4. The influence of radial RBC distribution, blood velocity profiles, and glycocalyx on coupled NO/O2 transport

5. Mathematical model of NO and O2 transport in an arteriole facilitated by hemoglobin based O2 carriers

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