Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity-Reference-Cited by-同舟云学术

Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity

Published:2021-05-01 Issue:5 Volume:130 Page:1398-1409
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Wang Ziyi¹²^ORCID,Rankine Leith²³,Bier Elianna. A.¹²,Mummy David²,Lu Junlan²³^ORCID,Church Alex²,Tighe Robert M.⁴,Swaminathan Aparna⁵,Huang Yuh-Chin T.⁵,Que Loretta G.⁵,Mammarappallil Joseph G.⁶,Rajagopal Sudarshan⁴⁷,Driehuys Bastiaan¹²³⁶

Affiliation:

1. Department of Biomedical Engineering, Duke University, Durham, North Carolina

2. Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina

3. Medical Physics Graduate Program, Duke University, Durham, North Carolina

4. Department of Medicine, Duke University Medical Center, Durham, North Carolina

5. Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Duke University Medical Center, Durham, North Carolina

6. Department of Radiology, Duke University Medical Center, Durham, North Carolina

7. Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina

Abstract

The diffusing capacity for carbon monoxide (DLCO) is perhaps one of the most comprehensive physiological measures used in pulmonary medicine. Here, we spatially resolve and estimate its key components—accessible alveolar volume, membrane, and capillary blood volume conductances—using hyperpolarized 129Xe MRI of ventilation, interstitial barrier uptake, and red blood cell transfer. This image-derived DLCO correlates strongly with measured values in 142 subjects with a broad range of pulmonary disorders.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00702.2020

Reference48 articles.

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2. Tissue-blood partition coefficient for xenon: temperature and hematocrit dependence