Soluble RAGE and skeletal muscle tissue RAGE expression profiles in lean and obese young adults across differential aerobic exercise intensities-Reference-Cited by-同舟云学术

Soluble RAGE and skeletal muscle tissue RAGE expression profiles in lean and obese young adults across differential aerobic exercise intensities

Published:2023-10-01 Issue:4 Volume:135 Page:849-862
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Miranda Edwin R.¹²^ORCID,Mey Jacob T.³^ORCID,Blackburn Brian K.⁴,Chaves Alec B.⁵^ORCID,Fuller Kelly N. Z.⁶,Perkins Ryan K.⁷,Ludlow Andrew T.¹,Haus Jacob M.¹⁸^ORCID

Affiliation:

1. School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States

2. Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States

3. Integrated Physiology and Molecular Metabolism, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

4. Applied Health Sciences and Kinesiology, Humboldt State University, Arcata, California, United States

5. Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States

6. Division of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

7. Department of Kinesiology, California State University Chico, Chico, California, United States

8. Applied Health Sciences, University of Illinois at Chicago, Chicago, Illinois, United States

Abstract

This study is the first to investigate the effects of aerobic exercise intensity on circulating sRAGE isoforms, muscle RAGE protein, and muscle RAGE splicing. sRAGE isoforms tended to diminish with exercise, although this effect was attenuated with increasing exercise intensity. Muscle RAGE protein and gene expression were unaffected by exercise. However, individuals with obesity displayed nearly twofold higher muscle RAGE protein and gene expression, which positively correlated with expression of the P65 subunit of NF-κB.

Funder

American Diabetes Association

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00748.2022

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