Skeletal muscle contraction kinetics and AMPK responses are modulated by the adenine nucleotide degrading enzyme AMPD1

Author:

Hafen Paul S.1ORCID,Law Andrew S.1,Matias Catalina1,Miller Spencer G.12,Brault Jeffrey J.1ORCID

Affiliation:

1. Department of Anatomy, Cell Biology & Physiology, Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana

2. Department of Kinesiology, East Carolina University, Greenville, North Carolina

Abstract

AMP deaminase 1 (AMPD1) deficiency has been associated with premature muscle fatigue and reduced work capacity, but this finding has been inconsistent. Herein, we report that although AMPD1 knockdown in mouse skeletal muscle does not change maximal isometric force, it negatively impacts muscle function by slowing contraction and relaxation kinetics in EDL muscle but not SOL muscle. Furthermore, AMPD1 knockdown differentially affects the [AMP]/AMPK responses to fatiguing contractions in an intensity-dependent manner in EDL muscle.

Funder

American Physiological Society

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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