A muscarinic, GIRK channel-mediated inhibition of inspiratory-related XII nerve motor output emerges in early postnatal development in mice-Reference-Cited by-同舟云学术

A muscarinic, GIRK channel-mediated inhibition of inspiratory-related XII nerve motor output emerges in early postnatal development in mice

Published:2023-11-01 Issue:5 Volume:135 Page:1041-1052
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Rudy Samantha L.¹,Wealing Jesse C.¹,Banayat Tatum²,Black Chody¹,Funk Gregory D.³⁴⁵^ORCID,Revill Ann L.¹²^ORCID

Affiliation:

1. Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona, United States

2. Department of Physiology, College of Graduate Studies, Midwestern University, Glendale, Arizona, United States

3. Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada

4. Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

5. Women and Children’s Health Research Institute, University of Alberta, Edmonton, Alberta, Canada

Abstract

Muscarinic modulation of inspiratory bursting at hypoglossal motoneurons has a net excitatory effect in neonatal rhythmic medullary slice preparations and a net inhibitory effect in adult animals. We demonstrate that muscarinic modulation of inspiratory bursting undergoes maturational changes from postnatal days 0 to 5 that include emergence of an inhibitory component mediated by G-protein-coupled inwardly rectifying potassium channels after postnatal day 3 in neonatal mouse rhythmic medullary slice preparations.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00042.2023

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