AltitudeOmics: effects of 16 days acclimatization to hypobaric hypoxia on muscle oxygen extraction during incremental exercise-Reference-Cited by-同舟云学术

AltitudeOmics: effects of 16 days acclimatization to hypobaric hypoxia on muscle oxygen extraction during incremental exercise

Published:2023-10-01 Issue:4 Volume:135 Page:823-832
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Bourdillon Nicolas¹^ORCID,Subudhi Andrew W.²,Fan Jui-Lin³^ORCID,Evero Oghenero⁴,Elliott Jonathan E.⁵,Lovering Andrew T.⁵^ORCID,Roach Robert C.⁴,Kayser Bengt¹^ORCID

Affiliation:

1. Institute of Sports Sciences, University of Lausanne, Lausanne, Switzerland

2. Hybl Sports Medicine and Performance Center, Department of Human Physiology and Nutrition, University of Colorado, Colorado Springs, Colorado, United States

3. Department of Physiology, Faculty of Medical & Health Sciences, Manaaki Manawa—The Centre for Heart Research, University of Auckland, Auckland, New Zealand

4. Altitude Research Center, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

5. Department of Human Physiology, University of Oregon, Eugene, Oregon, United States

Abstract

During incremental exercise muscle deoxyhemoglobin (HHb) and oxygen consumption (V̇o2) both increase linearly, and the slope of their relationship is an indirect index of local muscle O2 extraction. The latter was assessed at sea level, in acute and during chronic exposure to 5,260 m. The demonstrated presence of a muscle O2 extraction reserve during chronic exposure is coherent with previous studies indicating both limited muscle oxidative capacity and decrease in motor drive.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

U.S. Department of Defense

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00100.2023

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