Effects of acetazolamide on pulmonary artery pressure and prevention of high-altitude pulmonary edema after rapid active ascent to 4,559 m-Reference-Cited by-同舟云学术

Effects of acetazolamide on pulmonary artery pressure and prevention of high-altitude pulmonary edema after rapid active ascent to 4,559 m

Published:2022-06-01 Issue:6 Volume:132 Page:1361-1369
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Berger Marc Moritz¹^ORCID,Sareban Mahdi²³,Schiefer Lisa Maria⁴,Swenson Kai E.⁵,Treff Franziska⁴,Schäfer Larissa⁴,Schmidt Peter⁴,Schimke Magdalena M.⁴,Paar Michael⁶,Niebauer Josef²³^ORCID,Cogo Annalisa⁷,Kriemler Susi⁸,Schwery Stefan⁹,Pickerodt Philipp A.¹⁰^ORCID,Mayer Benjamin¹¹,Bärtsch Peter¹²,Swenson Erik R.¹³^ORCID

Affiliation:

1. Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany

2. University Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University, Salzburg, Austria

3. Research Institute of Molecular Sports Medicine and Rehabilitation, Paracelsus Medical University, Salzburg, Austria

4. Department of Anesthesiology, Critical Care and Pain Medicine, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria

5. Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts

6. Department of Radiology, Paracelsus Medical University, Salzburg, Austria

7. Biomedical Sport Studies Center, University of Ferrara, Ferrara, Italy

8. Department of Epidemiology, Biostatistics and Public Health Institute, University of Zürich, Zurich, Switzerland

9. Hospital of Valais, Sion, Switzerland

10. Department of Anesthesiology and Operative Intensive Care Medicine, Campus Charité Mitte and Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany

11. Institute for Epidemiology and Medical Biometry, Ulm University, Ulm, Germany

12. Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany

13. Department of Pulmonary, Critical Care and Sleep Medicine, VA Puget Sound Health Care System, University of Washington, Seattle, Washington

Abstract

This randomized, placebo-controlled, double-blind study is the first to investigate whether acetazolamide, which reduces acute mountain sickness (AMS), inhibits short-term hypoxic pulmonary vasoconstriction, and also prevents high-altitude pulmonary edema (HAPE) in a fast-climbing ascent to 4,559 m. We found no statistically significant reduction in HAPE incidence or differences in hypoxic pulmonary artery pressures compared with placebo despite reductions in AMS and greater ventilation-induced arterial oxygenation. Our data do not support recommending acetazolamide for HAPE prevention.

Funder

Deutsche Gesellschaft fur Berg- und Expeditionsmedizin

Salzburger Landesregierung

Wilderness Medical Society

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00806.2021

Reference44 articles.

1. Acute High-Altitude Illnesses