Prone position decreases acute lung inflammation measured by [<sup>11</sup>C](R)-PK11195 positron emission tomography in experimental acute respiratory distress syndrome-Reference-Cited by-同舟云学术

Prone position decreases acute lung inflammation measured by [¹¹C](R)-PK11195 positron emission tomography in experimental acute respiratory distress syndrome

Published:2023-02-01 Issue:2 Volume:134 Page:467-481
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Dhelft François¹²³,Lancelot Sophie³⁴⁵,Mouton William⁶,Le Bars Didier³⁴⁵,Costes Nicolas³⁴,Roux Emmanuel²,Orkisz Maciej²,Benzerdjeb Nazim⁷,Richard Jean-Christophe¹²³,Bitker Laurent¹²³^ORCID

Affiliation:

1. Service de Médecine Intensive – Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France

2. Univ Lyon, INSA‐Lyon, Université Claude Bernard Lyon 1, CNRS, Inserm, CREATIS UMR 5220, U1294, Villeurbanne, France

3. Claude Bernard University Lyon 1, Lyon, France

4. CERMEP – Imagerie du Vivant, Lyon, France

5. Hospices Civils de Lyon, Lyon, France

6. Laboratoire Commun de Recherche Hospices Civils de Lyon/bioMérieux, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France

7. Centre d’Anatomie et Cytologie Pathologique, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France

Abstract

Prone position decreases acute lung macrophage inflammation quantified in vivo with [11C](R)-PK11195 positron emission tomography in an experimental acute respiratory distress syndrome. Regional macrophage inflammation is maximal in the most anterior and posterior lung section of supine animals, in relation with increased regional tidal strain and hyperinflation, and reduced regional lung compliance.

Funder

Hospices Civils de Lyon

Société de Réanimation de Langue Française

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00234.2022

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4. Effect of Prone Position on Regional Shunt, Aeration, and Perfusion in Experimental Acute Lung Injury

5. Prone position reduces lung stress and strain in severe acute respiratory distress syndrome