Stretch-induced compliance mechanism in pregnancy-induced cardiac hypertrophy and the impact of cardiovascular risk factors-Reference-Cited by-同舟云学术

Stretch-induced compliance mechanism in pregnancy-induced cardiac hypertrophy and the impact of cardiovascular risk factors

Published:2024-05-01 Issue:5 Volume:326 Page:H1193-H1203
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Ferreira Ana Filipa¹^ORCID,Azevedo Maria João²³⁴⁵^ORCID,Morais Juliana¹,Almeida-Coelho João¹,Leite-Moreira André M.¹⁶,Lourenço André P.¹⁶^ORCID,Saraiva Francisca¹^ORCID,Diaz Sílvia O.¹^ORCID,Amador Ana Filipa⁷,Sousa Carla¹⁷,Machado Ana Paula⁸,Sampaio-Maia Benedita²³⁴^ORCID,Ramalho Carla⁴⁸⁹^ORCID,Leite-Moreira Adelino¹¹⁰,Barros António S.¹^ORCID,Falcão-Pires Inês¹^ORCID

Affiliation:

1. Cardiovascular Research and Development Unit, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal

2. Faculdade de Medicina Dentária, Universidade do Porto, Porto, Portugal

3. Instituto Nacional de Engenharia Biomédica, Porto, Portugal

4. i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

5. Academic Center for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

6. Anesthesiology Department, Centro Hospitalar Universitário de São João, Porto, Portugal

7. Cardiology Department, Centro Hospitalar Universitário de São João, Porto, Portugal

8. Obstetrics Department, Centro Hospitalar Universitário de São João, Porto, Portugal

9. Obstetrics, Gynaecology and Pediatrics Department, Faculty of Medicine of the University of Porto, Porto, Portugal

10. Cardiothoracic Surgery Department, Centro Hospitalar Universitário de São João, Porto, Portugal

Abstract

The sudden increase of volume overload triggers an acute myocardial stretch characterized by an immediate rise in contractility by the Frank–Starling mechanism, followed by a progressive increase known as the slow force response. The present study is the first to characterize echocardiographically the stretch-induced compliance (SIC) mechanism in the context of physiological hypertrophy induced by pregnancy. A distinct functional adaptation to SIC was observed between first and third trimesters, which was influenced by cardiovascular risk factors.

Funder

EC | European Regional Development Fund

Fundação para a Ciência e a Tecnologia

Sociedade Portuguesa de Cardiologia

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00701.2023

Reference57 articles.

1. Stretch-induced compliance: a novel adaptive biological mechanism following acute cardiac load

2. Acute Myocardial Response to Stretch: What We (don't) Know

3. Mechanisms contributing to cardiac remodelling

4. Echocardiographic Assessment of Cardiac Changes during Normal Pregnancy among Nigerians

5. Cardiovascular Physiology of Pregnancy