Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice-Reference-Cited by-同舟云学术

Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice

Published:2023-06-01 Issue:6 Volume:324 Page:H881-H892
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Andreassen Kristine¹²³^ORCID,Rixon Chloe²³^ORCID,Hansen Marie H.²³^ORCID,Hauge-Iversen Ida Marie²³^ORCID,Zhang Lili²,Sadredini Mani²³^ORCID,Erusappan Pugazendhi M.²^ORCID,Sjaastad Ivar²³^ORCID,Christensen Geir²³,Haugaa Kristina H.¹⁴⁵⁶^ORCID,Edvardsen Thor¹³⁵^ORCID,Lunde Ida G.²³⁷^ORCID,Stokke Mathis K.¹²³^ORCID

Affiliation:

1. Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

2. Institute for Experimental Medical Research, Oslo University Hospital Ullevål and University of Oslo, Oslo, Norway

3. K. G. Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway

4. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

5. ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

6. Faculty of Medicine, Karolinska Institute and Cardiovascular Division, Karolinska University Hospital, Stockholm, Sweden

7. Division of Diagnostics and Technology, Akershus University Hospital, Lørenskog, Norway

Abstract

Genotype-positive hypertrophic cardiomyopathy (HCM) mice had beneficial effects of exercise initiated before phenotype development. Exercised HCM mice had increased exercise capacity, smaller left atria, no increase in hypertrophy, or reduction of function, and a similar degree of fibrosis despite reduction of central extracellular matrix (ECM) genes, including collagens, compared with sedentary HCM mice.

Funder

Research Council of Norway

Ministry of Health and Care Services | Helse Sør-Øst RHF

Simon Fougner Hartmanns Familiefond

Stiftelsen Kristian Gerhard Jebsen

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00701.2022

Reference48 articles.

1. Prevalence of Hypertrophic Cardiomyopathy in a General Population of Young Adults

2. Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy

3. Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy

4. Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology

5. Biomarkers of cardiovascular stress and fibrosis in preclinical hypertrophic cardiomyopathy