PPARα agonists acutely inhibit calcium-independent PLA2 to reduce H2O2-induced contractions in aortae of spontaneously hypertensive rats
Author:
Affiliation:
1. The University of Hong Kong
Publisher
American Physiological Society
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology
Link
http://www.physiology.org/doi/pdf/10.1152/ajpheart.00314.2017
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1. Cytosolic 85-kDa Phospholipase A2-mediated Release of Arachidonic Acid Is Critical for Proliferation of Vascular Smooth Muscle Cells
2. Thromboxane A2 receptor antagonists inhibit endothelium-dependent contractions.
3. Interleukin-2 causes endothelium-dependent contractions to arachidonic acid.
4. Hydrogen peroxide is an endothelium-dependent contracting factor in rat renal artery
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