Cardiac electrophysiology studies in mice via the transjugular route: a comprehensive practical guide

Author:

Favere Kasper1234ORCID,Van fraeyenhove Jens1,Jacobs Griet1ORCID,Bosman Matthias1,Eens Sander12,De Sutter Johan4,Miljoen Hielko3,Guns Pieter-Jan1ORCID,De Keulenaer Gilles W.15,Segers Vincent F. M.123ORCID,Heidbuchel Hein23

Affiliation:

1. Laboratory of Physiopharmacology, GENCOR, University of Antwerp, Antwerp, Belgium

2. Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, Antwerp, Belgium

3. Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium

4. Department of Internal Medicine, Ghent University, Ghent, Belgium

5. Department of Cardiology, ZNA Middelheim Hospital, Antwerp, Belgium

Abstract

Electrophysiology studies (EPS) allow in-depth evaluation of cardiac electrophysiology and -pathology. These techniques have been adapted to the murine setting for (translational) studies, mainly focusing on arrhythmogenesis. Despite the frequent application of EPS via the transjugular route, a thorough description of the technique is currently lacking. This article aims to function as a comprehensive guide, also elaborating (for the first time) on nonsurgical aspects such as catheter positioning, tracing artifacts, stimulation protocols, and reference values.

Funder

Industrial Research Fund/Strategic Basic Research

Geconcerteerde Onderzoeksactie

European Union | Seventh Framework Programme | ERA.Net RUS Plus

Vlaamse Interuniversitaire Raad/Interuniversitair Bijzonder OnderzoeksFonds

European Union | Horizon 2020 | INSPIRE

Fonds Wetenschappelijk Onderzoek

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Intracardiac electrophysiology to characterize susceptibility to ventricular arrhythmias in murine models;Frontiers in Physiology;2024-01-23

2. A comprehensive protocol combining in vivo and ex vivo electrophysiological experiments in an arrhythmogenic animal model;American Journal of Physiology-Heart and Circulatory Physiology;2024-01-01

3. Improving rigor and reproducibility in cardiovascular research;American Journal of Physiology-Heart and Circulatory Physiology;2023-10-01

4. A Minimally Invasive Approach for Cardiac Electrophysiology Studies in Mice;International Journal of Drug Discovery and Pharmacology;2023-03-25

5. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals;American Journal of Physiology-Heart and Circulatory Physiology;2022-12-01

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