Neuraminidase inhibition improves endothelial function in diabetic mice-Reference-Cited by-同舟云学术

Neuraminidase inhibition improves endothelial function in diabetic mice

Published:2023-12-01 Issue:6 Volume:325 Page:H1337-H1353
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Foote Christopher A.¹²,Ramirez-Perez Francisco I.¹^ORCID,Smith James A.¹³,Ghiarone Thaysa¹,Morales-Quinones Mariana¹^ORCID,McMillan Neil J.¹³^ORCID,Augenreich Marc A.¹³^ORCID,Power Gavin¹³,Burr Katherine¹,Aroor Annayya R.⁴⁵,Bender Shawn B.⁵⁶^ORCID,Manrique-Acevedo Camila¹⁴⁵^ORCID,Padilla Jaume¹³⁵^ORCID,Martinez-Lemus Luis A.¹²⁷^ORCID

Affiliation:

1. NextGen Precision Health, University of Missouri, Columbia, Missouri, United States

2. Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States

3. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States

4. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri, United States

5. Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, United States

6. Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, United States

7. Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri, United States

Abstract

This work identifies neuraminidase as a key mediator of endothelial dysfunction in type 2 diabetes that may serve as a biomarker for impaired endothelial function and predictive of development and progression of cardiovascular pathologies associated with type 2 diabetes (T2D). Data show that intervention with the neuraminidase inhibitor zanamivir at effective plasma concentrations may represent a novel pharmacological strategy for restoring the glycocalyx and ameliorating endothelial dysfunction.

Funder

HHS | NIH | NHLBI | NHLBI Division of Intramural Research

National Science Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00337.2023

Reference107 articles.

1. Mechanisms of Diabetic Complications

2. The Pathobiology of Diabetic Complications

3. Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention

4. Cardiovascular Disease in Type 2 Diabetes From Population to Man to Mechanisms

5. Cellular and molecular mechanisms of endothelial dysfunction in diabetes

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