Quantification of true lumen helical morphology and chirality in type B aortic dissections

Author:

Bondesson Johan1ORCID,Suh Ga-Young23,Lundh Torbjörn4,Dake Michael D.5,Lee Jason T.3,Cheng Christopher P.3

Affiliation:

1. Division of Dynamics, Chalmers University of Technology, Gothenburg, Sweden

2. Department of Biomedical Engineering, California State University, Long Beach, California

3. Division of Vascular Surgery, Stanford University, Stanford, California

4. Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden

5. Department of Surgery, University of Arizona, Tucson, Arizona

Abstract

A novel definition of helical propagation of type B aortic dissections reveals a distinct bimodality, with the true lumen being either achiral (nonhelical) or exclusively right-handed. This right-handed chirality is consistent with anatomic and physiological phenomena such as right-handed twist during left ventricle contraction, helical blood flow, and tissue fiber direction. The helical character of aortic dissections may be useful for pathology research, diagnostics, treatment selection, therapeutic durability prediction, and aortic device design.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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