Association between serum estradiol and cardiovascular health among transgender adults using gender-affirming estrogen therapy

Author:

Rytz Chantal L.12ORCID,Miranda Keila Turino3,Ronksley Paul E.45ORCID,Saad Nathalie6,Raj Satish R.127ORCID,Somayaji Ranjani689,Dumanski Sandra M.125ORCID,Ganshorn Heather10ORCID,Greene Dina N.11,Collister David121314ORCID,Newbert Amelia M.15,Peace Lindsay15,Ahmed Sofia B.2131416ORCID

Affiliation:

1. Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada

2. Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

3. Cardiovascular Health and Autonomic Regulation Laboratory, Department of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada

4. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada

5. O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

6. Department of Medicine, University of Calgary, Calgary, Alberta, Canada

7. Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada

8. Department of Microbiology, Immunology and Infectious Disease, University of Calgary, Calgary, Alberta, Canada

9. Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

10. Libraries and Cultural Resources, University of Calgary, Calgary, Alberta, Canada

11. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States

12. Population Health Research Institute, Hamilton, Ontario, Canada

13. Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

14. Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

15. Skipping Stone Foundation, Calgary, Alberta, Canada

16. Women and Children’s Health Research Institute, University of Alberta, Edmonton, Albert, Canada

Abstract

In this systematic review and meta-analysis of 35 studies involving 7,745 participants, high rates of serum estradiol change were associated with small increases in body mass index. Moderate to high rates of change were associated with decreases in low-density lipoprotein. Low rates of change were associated with small decreases in systolic blood pressure. Rate of serum estradiol change in adults using gender-affirming estrogen therapy may influence cardiovascular risk factors, though further research is warranted.

Funder

Canadian Institute of Health Research

Publisher

American Physiological Society

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