Affiliation:
1. Department of Medicine, University of California, San Diego, La Jolla, California
Abstract
Several studies indicated the importance of ALPK2 for cardiac function and development. A recent study in zebrafish report that loss of ALPK2 leads to severe cardiac defects. In contrast, murine Alpk2-gKO models developed in this work display no overt cardiac phenotype. Our results suggest ALPK2, as a rapidly evolving gene, lost its essential cardiac functions in mammals.
Funder
NIGMS
HHS | NIH | National Institute of Neurological Disorders and Stroke
Publisher
American Physiological Society
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology
Cited by
3 articles.
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