Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals

Author:

Ziogos Efthymios12,Kwapong Yaa A.1,Weiss Robert G.23,Schär Michael3ORCID,Brown Todd T.4,Bagchi Shashwatee56ORCID,Soleimanifard Alborz2,Harb Tarek12,Piggott Damani A.7,Gerstenblith Gary12,Leucker Thorsten M.12ORCID,Hays Allison G.12ORCID

Affiliation:

1. Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

2. Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

3. Division of Magnetic Resonance Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

4. Division of Endocrinology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

5. Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States

6. Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States

7. Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Abstract

This is the first study to examine the relationship between age and coronary endothelial function (CEF) in people with human immunodeficiency virus (HIV) (PWH). CEF was assessed using magnetic resonance imaging (MRI) in people with and without HIV. Although age and CEF were significantly inversely related in individuals without HIV, there was no association between age and CEF in PWH.

Funder

Johns Hopkins Center for AIDS Research

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

Clarence Doodeman Endowment in Cardiology

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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