Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging-Reference-Cited by-同舟云学术

Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging

Published:2023-11-01 Issue:5 Volume:325 Page:H965-H982
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Vue Zer¹,Neikirk Kit¹,Vang Larry¹,Garza-Lopez Edgar²,Christensen Trace A.³,Shao Jianqiang⁴,Lam Jacob²^ORCID,Beasley Heather K.¹^ORCID,Marshall Andrea G.¹^ORCID,Crabtree Amber¹^ORCID,Anudokem Josephs¹^ORCID,Rodriguez Benjamin¹,Kirk Benjamin²,Bacevac Serif²,Barongan Taylor¹^ORCID,Shao Bryanna¹,Stephens Dominique C.¹⁵,Kabugi Kinuthia¹,Koh Ho-Jin⁶,Koh Alice¹,Evans Chantell S.⁷^ORCID,Taylor Brittany⁸,Reddy Anilkumar K.⁹,Miller-Fleming Tyne¹⁰,Actkins Ky’Era V.¹⁰,Zaganjor Elma¹,Daneshgar Nastaran¹¹^ORCID,Murray Sandra A.¹²^ORCID,Mobley Bret C.¹³,Damo Steven M.⁵,Gaddy Jennifer A.¹³¹⁴¹⁵,Riggs Blake¹⁶,Wanjalla Celestine¹⁷^ORCID,Kirabo Annet¹⁷^ORCID,McReynolds Melanie¹⁸,Gomez Jose A.¹⁴^ORCID,Phillips Mark A.¹⁹,Exil Vernat²⁰²¹,Dai Dao-Fu²²,Hinton Antentor¹^ORCID

Affiliation:

1. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States

2. Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States

3. Microscopy and Cell Analysis Core Facility, Mayo Clinic, Rochester, Minnesota, United States

4. Central Microscopy Research Facility, University of Iowa, Iowa City, Iowa, United States

5. Department of Life and Physical Sciences, Fisk University, Nashville, Tennessee, United States

6. Department of Biological Sciences, Tennessee State University, Nashville, Tennessee, United States

7. Department of Cell Biology, Duke University School of Medicine, Durham, North Carolina, United States

8. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, United States

9. Department of Medicine, Baylor College of Medicine, Houston, Texas, United States

10. Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States

11. Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States

12. Department of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

13. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States

14. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States

15. Tennessee Valley Healthcare Systems, United States Department of Veterans Affairs, Nashville, Tennessee, United States

16. Department of Biology at San Francisco State University, San Francisco, California, United States

17. Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States

18. Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States

19. Department of Integrative Biology, Oregon State University, Corvallis, Oregon, United States

20. Division of Cardiology, Department of Pediatrics, St. Louis University School of Medicine, St. Louis, Missouri, United States

21. Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States

22. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Abstract

This article shows how mitochondria in murine cardiac changes, importantly elucidating age-related changes. It also is the first to show that the MICOS complex may play a role in outer membrane mitochondrial structure.

Funder

CZI Science Diversity Leadership

United Negro College Fund/Bristol-Myers Squibb

Vanderbilt Diabetes and Research Training Center for DRTC Alzheimer’s Disease Pilot & Feasibility Program

Burroughs Wellcome Fund

HHS | NIH | National Institute of Child Health and Human Development

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of General Medical Sciences

HHS | National Institutes of Health

National Science Foundation

U.S. Department of Veterans Affairs

Publisher