Obesity-related vascular dysfunction persists after weight loss and is associated with decreased vascular glucagon-like peptide receptor in female rats

Author:

Kiernan Risa1ORCID,Persand Dhandevi1,Maddie Nicole1,Cai Weikang1,Carrillo-Sepulveda Maria Alicia1ORCID

Affiliation:

1. Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, New York City, New York

Abstract

Although short-term weight loss successfully improved metabolic parameters, it failed to correct vascular dysfunction present in obese female rats. Vascular GLP-1/Akt signaling was decreased in both obese rats and those with short-term weight loss, suggesting it may be a potential target for therapeutic intervention in obesity-related persistent vascular dysfunction in obese females.

Funder

New York Institute of Technology

American Heart Association

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of Mental Health

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Sex as a biological variable for cardiovascular physiology;American Journal of Physiology-Heart and Circulatory Physiology;2024-03-01

2. Decaffeinated green tea and green coffee extracts as metformin's add-on enhance metabolic syndrome risk factors and improve the cardiac insulin-gene-related pathway;Journal of Pharmacy & Pharmacognosy Research;2023-05-01

3. An American Physiological Society cross-journal Call for Papers on “The Physiology of Obesity”;American Journal of Physiology-Lung Cellular and Molecular Physiology;2022-11-01

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