Evidence for association of coronary sinus levels of hepatocyte growth factor and collateralization in human coronary disease

Author:

Lenihan Daniel J.1,Osman Abdulfatah2,Sriram Vissa2,Aitsebaomo Julius3,Patterson Cam3

Affiliation:

1. Cardiovascular Specialists of Texas, Texas City, 77565;

2. Division of Cardiology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555;

3. Carolina Cardiovascular Biology Center and Departments of Medicine, Pharmacology, and Cell and Developmental Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7075

Abstract

The therapeutic use of angiogenic factors to protect ischemic myocardium is limited by our incomplete understanding of their endogenous production. We determined the association between angiogenic factors and collateral formation in patients with coronary artery disease (CAD). A total of 71 patients underwent catheterization with sampling of the pulmonary artery, aorta, and coronary sinus (CS) to determine the levels of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF). VEGF and HGF levels were not different in the three vascular sites, suggesting that the heart is not a major source of these cytokines in the circulation. CS VEGF and HGF levels were similar in patients with and without CAD. Elevated CS HGF levels were associated with collateral formation, whereas VEGF levels were not. Additionally, CS HGF was significantly elevated in patients with left ventricular dysfunction. These data map for the first time the concentration of endogenous angiogenic factors in the coronary circulation and support further studies to determine whether HGF may be an endogenous cardioprotective angiogenic factor.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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