The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms-Reference-Cited by-同舟云学术

The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms

Published:2024-03-01 Issue:3 Volume:326 Page:H623-H635
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Hansen Thomas S.¹²,Karimi Galougahi Keyvan²,Tang Owen¹²^ORCID,Tsang Michael¹²,Scherrer-Crosbie Marielle³,Arystarkhova Elena⁴,Sweadner Kathleen⁴,Bursill Christina²⁵,Bubb Kristen J.¹²⁶^ORCID,Figtree Gemma A.¹²

Affiliation:

1. Kolling Institute, University of Sydney, Sydney, New South Wales, Australia

2. Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia

3. Perelman School of Medicine, The Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States

4. Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, United States

5. Vascular Research Centre, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia

6. Biomedicine Discovery Institute and Victorian Heart Institute, Monash University Faculty of Medicine, Nursing and Health Sciences, Clayton, Victoria, Australia

Abstract

This is the first study to show that deficiency of the FXYD1 protein is associated with pulmonary hypertension. FXYD1 expression is lower in the lungs of people with idiopathic pulmonary artery hypertension. FXYD1 deficiency results in both left and right ventricular functional impairment. Finally, FXYD1 may endogenously protect the heart from oxidative and inflammatory injury.

Funder

National Health and Medical Research Council Australia

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00090.2023

Reference50 articles.

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5. Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: Implications for angiotensin II-induced vascular dysfunction

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