Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium

Author:

Lang Di1ORCID,Medvedev Roman Y.1ORCID,Ratajczyk Lucas1,Zheng Jingjing1,Yuan Xiaoyu1,Lim Evi1,Han Owen Y.1,Valdivia Hector H.1,Glukhov Alexey V.1ORCID

Affiliation:

1. Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin

Abstract

Mouse and human atrial myocardium demonstrate high variability in the organization of the transversal-axial tubule system (TATS), with more organized TATS expressed in the right atrial appendage. TATS distribution governs anatomical heterogeneity of Ca2+ dynamics and thus could contribute to integral atrial contractility, mechanics, and arrhythmogenicity.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

University of Wisconsin Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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