Amiodarone prevents wave front-tail interactions in patients with heart failure: an in silico study-Reference-Cited by-同舟云学术

Amiodarone prevents wave front-tail interactions in patients with heart failure: an in silico study

Published:2023-11-01 Issue:5 Volume:325 Page:H952-H964
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Gray Richard A.¹^ORCID,Franz Michael R.²³

Affiliation:

1. Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, United States

2. Cardiology Division, Veteran Affairs Medical Center, Washington, District of Columbia, United States

3. Department of Pharmacology, Georgetown University Medical Center, Washington, District of Columbia, United States

Abstract

This work presents a new model of the action potential of the human, which reproduces the complex dynamics during premature stimulation in heart failure patients with and without amiodarone. A specific mechanism of the ability of amiodarone to prevent reentrant arrhythmias is presented.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00227.2023

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