Exercise-mitigated sex-based differences in aging: from genetic alterations to heart performance-Reference-Cited by-同舟云学术

Exercise-mitigated sex-based differences in aging: from genetic alterations to heart performance

Published:2021-02-01 Issue:2 Volume:320 Page:H854-H866
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Börzsei Denise¹,Priksz Dániel²,Szabó Renáta¹³,Bombicz Mariann²,Karácsonyi Zoltán⁴,Puskás László G.⁵⁶,Fehér Liliána Z.⁵,Radák Zsolt⁷,Kupai Krisztina¹,Berkó Anikó Magyariné¹^ORCID,Varga Csaba¹,Juhász Béla²,Pósa Anikó¹³

Affiliation:

1. Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary

2. Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

3. Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary

4. Department of Orthopedics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

5. Avidin Limited, Szeged, Hungary

6. Laboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary

7. Research Institute of Sport Science, University of Physical Education, Budapest, Hungary

Abstract

Voluntary exercise has proved to be an effective therapeutic tool to improve cardiac function in aged rats with clearly visible sex differences. Long-term exercise is associated with decreased Ogn and Comt expression and enhanced presence of Pcp4 and Esm1 genes. Sex-dependent changes were also observed in the expression of the cardiovascular key proteins. Fundamental alterations in gene and protein expression may contribute to the improvement of cardiac performance.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00643.2020

Reference47 articles.

1. Role of Heme Oxygenases in Cardiovascular Syndromes and Co-morbidities

2. Editorial (Thematic Issues: Pharmacological Mechanisms and Interventions in Ischemia/ Reperfusion-Induced Injury)

3. Gut dysbiosis: a potential link between increased cancer risk in ageing and inflammaging

4. Management of multicellular senescence and oxidative stress

5. Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Status of Research on Sestrin2 and Prospects for its Application in Therapeutic Strategies Targeting Myocardial Aging;Current Problems in Cardiology;2023-12

2. Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?;International Journal of Molecular Sciences;2023-11-18

3. Involvement of the Endocannabinoid System in the Control of Pain and Obesity by Exercise in Rodents: A Systematic Review;Cannabis and Cannabinoid Research;2023-06-01

4. Drosophila exercise, an emerging model bridging the fields of exercise and aging in human;Frontiers in Cell and Developmental Biology;2022-09-09

5. Reevaluating methods reporting practices to improve reproducibility: an analysis of methodological rigor for the Langendorff whole heart technique;American Journal of Physiology-Heart and Circulatory Physiology;2022-09-01