The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model-Reference-Cited by-全球学者库

The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

Published:2022-01-01 Issue:1 Volume:30 Page:9-18
ISSN:2284-5623
Container-title:Revista Romana de Medicina de Laborator
language:en
Short-container-title:

Author:

Avnioglu Seda¹,Güngör Meltem²,Kurutas Ergul³,Ozturk Unal⁴,Demirhan Ilter⁵,Bakaris Sevgi⁶,Velioglu Halil A.⁷,Cankaya Seyda⁸,Yulug Burak⁸

Affiliation:

1. Department of Anatomy , Alanya Alaaddin Keykubat University, Faculty of Medicine , Turkey

2. Department of Medical Biochemistry , Sanko University, Faculty of Medicine , Turkey

3. Department of Medical Biochemistry , Kahramanmaras Sutcu Imam University, Faculty of Medicine , Turkey

4. Department of Cardiology , Kahramanmaras Sutcu Imam University, Faculty of Medicine , Turkey

5. Department of Electronics-Automation Biomedical Device Technology Program , Harran University, Vocational School of Health Services , Turkey

6. Department of Pathology , Kahramanmaras Sutcu Imam University, Faculty of Medicine , Turkey

7. Restorative and Regenerative Medicine Center , İstanbul Medipol University , Turkey

8. Department of Neurology , Alanya Alaaddin Keykubat University, Faculty of Medicine , Turkey

Abstract

Abstract Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/rrlm-2021-0036

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