MMP-2 and MMP-9 gene polymorphisms and risk of head and neck carcinomas

Author:

Schipor Sorina1,Zamfir Adina2,Gheorghe Dan Cristian3,Picu Catalina14,Manda Dana1

Affiliation:

1. Research Department , “C. I. Parhon” National Institute of Endocrinology , Romania

2. Otorhinolaryngology, “Grigore Alexandrescu” Children Hospital , Romania

3. Otorhynolaryngology, “Carol Davila” University of Medicine and Pharmacy , Romania

4. Faculty of Biology , University of Bucharest , Romania

Abstract

Abstract Background: Head and neck carcinomas (HNC) account for a majority of ear, nose and throat tumours. They account for 6.3% of all incident malignancies and 6.2 % of all deaths from cancer in Romania in 2020, the fifth most common cancer in this Eastern Europe country. Aim of the study: The aim of our study was to investigate the association between two MMP-2 and MMP-9 promoter gene polymorphisms and head and neck cancer. Methods. We enrolled 142 subjects, 65 cancer patients, and 77 control subjects and tested them for MMP-2 -735 C/T and MMP-9 -1562 C/T polymorphisms by PCR-RFLP. Results. Comparison between cancer patients and controls demonstrated the presence of MMP-2 -735 C/T and MMP-9 -1562 C/T in head and neck malignant tumours, with OR = 2.206 (95% CI 1.058-4.599, P = 0.03) for MMP-2 and OR = 2.748 (95% C.I. 1.262-5.981, P=0.009) for MMP-9 gene polymorphism. This means that the presence of T allele could be a risk factor for head and neck cancer development. The analysis included a stratification of studied groups by age and gender. Conclusions. Both genotypes were associated with a significant risk for head and neck carcinomas in case of the presence of the T allele. MMP-2 -735 C/T (rs2285053) and MMP-9 -1562 C/T (rs3918242) gene polymorphism could be an important genetic marker for head and neck cancer susceptibility. This finding could be useful for genetic screening in head and neck carcinomas.

Publisher

Walter de Gruyter GmbH

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