1. Translational and Clinical Research Institute, Faculty of Medical Sciences, The Medical School, Newcastle University, Framlington Place , Newcastle upon Tyne , NE2 4HH , UK
2. Northern Centre for Mood Disorders, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle University , Newcastle upon Tyne , NE4 5PL , UK
3. Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, St. Nicholas Hospital , Jubilee Road, Gosforth , Newcastle upon Tyne , NE3 3XT , UK
4. School of Natural and Environmental Science, Agriculture Building, Newcastle University , King’s Road , Newcastle upon Tyne , NE1 7RU , UK
5. National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre, Biomedical Research Building, Campus for Ageing and Vitality , Newcastle upon Tyne , NE4 5PL , UK
6. NIHR Newcastle Clinical Research Facility, Level 6, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust , Queen Victoria Road , Newcastle upon Tyne , NE1 4LP , UK