Exploring the microscopic terrain of the small intestinal epithelium: a comprehensive overview of general architecture and the present understanding of intestinal stem cells

Author:

Nowak Bernadetta1,Wanat Marta1,Świątko Ada1,Mirkowski Karol1,Tarkowski Victoria1,Mrożek Andrzej1,Mazurek Mateusz1,Domanski Jurand2,Domagała Zygmunt2

Affiliation:

1. 1 Clinical and Dissecting Anatomy Students Scientific Club , Wroclaw Medical University , Wroclaw , Poland

2. 2 Division of Anatomy, Department of Human Morphology and Embryology , Wroclaw Medical University , Wroclaw , Poland

Abstract

Abstract This paper provides a comprehensive overview of the microscopic landscape of the small intestinal epithelium, focusing on its general structure and the current state of knowledge regarding intestinal stem cells. The small intestine’s epithelial layer is intricately organized, comprising various cell types with specialized functions, including goblet cells, enterocytes, enteroendocrine cells, Paneth cells, microfold cells (M cells), and tuft cells. These cells collectively contribute to essential physiological processes such as digestion, absorption, and immune response regulation. The review delves into the role of intestinal stem cells, residing in the crypts, and their significance in maintaining tissue homeostasis and regeneration. Understanding the microscopic intricacies of the small intestinal epithelium is crucial for unraveling its physiological functions and exploring potential therapeutic avenues.

Publisher

Walter de Gruyter GmbH

Subject

Cell Biology,Molecular Biology

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