Association of Relative Telomere Length and Risk of High Human Papillomavirus Load in Cervical Epithelial Cells-Reference-Cited by-同舟云学术

Association of Relative Telomere Length and Risk of High Human Papillomavirus Load in Cervical Epithelial Cells

Published:2021-11-01 Issue:2 Volume:24 Page:65-70
ISSN:1311-0160
Container-title:Balkan Journal of Medical Genetics
language:en
Short-container-title:

Author:

Albosale A H¹²,Mashkina E V²

Affiliation:

1. Department of Medical Laboratory Techniques , Al-Dour Technical Institute, Northern Technical University , Mosul , Iraq

2. Genetics Department of Academy of Biology and Biotechnology , Southern Federal University , Rostov-on-Don , Russia

Abstract

Abstract Importunate high-risk HPV (HR-HPV) infection is the most common trigger for the cervical carcinogenesis process. In this respect, the presence of cancer can be imputed to telomere lengthening or shortening. This paper explores the possible correlation between relative telomere length and viral load in two groups of women, namely: those with high-risk HPV infection and those who do not have this infection. Thus, samples comprising of 50 women in each group were evaluated for this research. The Amplisens HPV HCR screen-titre-FRT PCR kite was employed for quantitative analysis. Relative telomere length was quantified by real-time PCR. In each of the two HPV load groups, there was no correlation between age and telomere length. Telomere shortening was found in the cervical cell samples of women with high HPV loads, compared with women in the control group. Telomere shortening is associated with elevated HPV loads.

Publisher

Walter de Gruyter GmbH

Subject

Genetics (clinical),Genetics

Link

https://www.sciendo.com/pdf/10.2478/bjmg-2021-0026

Reference37 articles.

1. Herrmann M, Pusceddu I, März W, Herrmann W. Telomere biology and age-related diseases. Clin Chem Lab Med. 2018; 56(8): 1210–1222.

2. Armstrong CA, Tomita K. Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells. Open Biol. 2017;7(3): 160338.

3. Bernal A, Tusell L. Telomeres: Implications for Cancer Development. Int J Mol Sci. 2018; 19(1): 294.

4. Zhu X, Han W, Xue W, Zou Y, Xie C, Du J, et al. The association between telomere length and cancer risk in population studies. Sci Rep. 2016; 6(1): 22243.

5. Caocci G, Greco M, Delogu G, Secchi C, Martino B, Labate C, et al. Telomere length shortening is associated with treatment-free remission in chronic myeloid leukemia patients. J Hematol Oncol. 2016; 9(1): 63.