Association of Non-Invasive Markers of Liver Fibrosis with HCV Coinfection and Antiretroviral Therapy in Patients with HIV

Author:

Koļesova Oksana1,Eglīte Jeļena1,Koļesovs Aleksandrs2,Krūmiņa Angelika3,Ekšteina Ilze3,Madelāne Monta3,Vīksna Ludmila3

Affiliation:

1. Joint Laboratory of Clinical Immunology and Immunogenetics , Rīga Stradiņš University , 5 Rātsupītes Str., Rīga , LV- 1067 , Latvia

2. Department of Psychology , University of Latvia , 1 Imantas 7 th line, Rīga , Latvia

3. Rīga Stradiņš University , Department of Infectology and Dermatology , 3 Linezera Str., Rīga , LV- 1006 , Latvia

Abstract

Abstract The aim of this study was to assess the main effects and interaction between viral hepatitis C (HCV) coinfection and antiretroviral therapy (ART) by using a nonparametric ANOVA on direct and indirect markers of liver fibrosis in HIV-infected patients. The sample included 178 HIV patients aged from 23 to 65 (36% females). The following parameters were determined in blood of patients: hyaluronic acid, pro-matrix metalloproteinase-1, alanine aminotransferase, aspartate aminotransferase, and platelet count. The FIB-4 index was also calculated. The nonparametric ANOVA revealed no significant interaction between HCV coinfection and ART. This provides evidence for an independent contribution of each factor on promotion of the pathology. The results also demonstrated that the direct and indirect indicators of liver fibrosis are associated differently with the studied factors. Therefore, a combination of markers should be used for monitoring of liver fibrosis in HIV-infected patients.

Publisher

Walter de Gruyter GmbH

Subject

Multidisciplinary

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