Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations-Reference-Cited by-同舟云学术

Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations

Published:2024 Issue:1 Volume:42 Page:202
ISSN:2287-4208
Container-title:The World Journal of Men's Health
language:en
Short-container-title:World J Mens Health

Author:

Agarwal Ashok¹²^ORCID,Farkouh Ala’a¹^ORCID,Saleh Ramadan¹³^ORCID,Hamoda Taha Abo-Almagd Abdel-Meguid¹⁴⁵^ORCID,Salvio Gianmaria¹⁶^ORCID,Boitrelle Florence¹⁷⁸^ORCID,Harraz Ahmed M.¹⁹¹⁰¹¹^ORCID,Ghayda Ramy Abou¹¹²^ORCID,Kavoussi Parviz¹¹³^ORCID,Gül Murat¹¹⁴^ORCID,Toprak Tuncay¹¹⁵^ORCID,Russo Giorgio Ivan¹¹⁶^ORCID,Durairajanayagam Damayanthi¹¹⁷^ORCID,Rambhatla Amarnath¹¹⁸^ORCID,Birowo Ponco¹¹⁹^ORCID,Cannarella Rossella¹²⁰²¹^ORCID,Phuoc Nguyen Ho Vinh¹²²²³^ORCID,Zini Armand¹²⁴^ORCID,Arafa Mohamed¹²⁵²⁶²⁷^ORCID,Wyns Christine¹²⁸^ORCID,Tremellen Kelton¹²⁹^ORCID,Sarıkaya Selçuk¹³⁰^ORCID,Lewis Sheena¹³¹^ORCID,Evenson Donald P.¹³²^ORCID,Ko Edmund¹³³^ORCID,Calogero Aldo E.¹¹⁰^ORCID,Bahar Fahmi¹³⁴^ORCID,Martínez Marlon¹³⁵^ORCID,Ambar Rafael F.¹³⁶³⁷^ORCID,Colpi Giovanni M.¹³⁸^ORCID,Bakircioglu Mustafa Emre¹³⁹^ORCID,Henkel Ralf¹⁴⁰⁴¹^ORCID,Kandil Hussein¹⁴²^ORCID,Serefoglu Ege Can¹⁴³^ORCID,Alfakhri Abdullah¹⁴⁴^ORCID,Tsujimura Akira¹⁴⁵^ORCID,Kheradmand Alireza¹⁴⁶^ORCID,Marino Angelo¹⁴⁷^ORCID,Adamyan Aram¹⁴⁸^ORCID,Zilaitiene Birute¹⁴⁹^ORCID,Ozer Cevahir¹⁵⁰^ORCID,Pescatori Edoardo¹⁵¹^ORCID,Vogiatzi Paraskevi¹⁵²^ORCID,Busetto Gian Maria¹⁵³^ORCID,Balercia Giancarlo¹⁶^ORCID,Elbardisi Haitham¹²⁵²⁶⁵⁴^ORCID,Akhavizadegan Hamed¹⁵⁵^ORCID,Sajadi Hesamoddin¹⁵⁶^ORCID,Taniguchi Hisanori¹⁵⁷^ORCID,Park Hyun Jun¹⁵⁸⁵⁹^ORCID,Maldonado Rosas Israel¹⁶⁰^ORCID,Al-Marhoon Mohamed¹⁶¹^ORCID,Sadighi Gilani Mohammad Ali¹⁵⁶^ORCID,Alhathal Naif¹⁶²^ORCID,Quang Nguyen¹⁶³⁶⁴^ORCID,Pinggera Germar-Michael¹⁶⁵^ORCID,Kothari Priyank¹⁶⁶^ORCID,Micic Sava¹⁶⁷^ORCID,Homa Sheryl¹⁶⁸^ORCID,Long Tran Quang Tien¹⁶⁹^ORCID,Zohdy Wael¹²⁷^ORCID,Atmoko Widi¹¹⁹^ORCID,Ibrahim Wael¹⁷⁰^ORCID,Sabbaghian Marjan¹⁵⁶^ORCID,Abumelha Saad Mohammed¹⁷¹^ORCID,Chung Eric¹⁷²^ORCID,Ugur Muhammet Rasit¹⁷³^ORCID,Ozkent Mehmet Serkan¹⁷⁴^ORCID,Selim Osama¹²⁷^ORCID,Darbandi Mahsa¹⁷⁵⁷⁶^ORCID,Fukuhara Shinichiro¹⁷⁷^ORCID,Jamali Mounir¹⁷⁸^ORCID,de la Rosette Jean¹⁷⁹^ORCID,Kuroda Shinnosuke²¹^ORCID,Smith Ryan P.¹⁸⁰^ORCID,Baser Aykut¹⁸¹^ORCID,Kalkanli Arif¹⁸²^ORCID,Tadros Nicholas N.¹⁸³^ORCID,Aydos Kaan¹⁸⁴^ORCID,Mierzwa Tiago Cesar¹⁸⁵^ORCID,Khalafalla Kareim¹²⁵⁸⁶⁸⁷^ORCID,Malhotra Vineet¹⁸⁸^ORCID,Moussa Mohamad¹⁸⁹⁹⁰^ORCID,Finocchi Federica¹⁶^ORCID,Rachman Rinaldo Indra¹¹⁹^ORCID,Giulioni Carlo¹⁶^ORCID,Avidor-Reiss Tomer¹⁹¹⁹²^ORCID,Kahraman Oguzhan¹⁵¹^ORCID,Çeker Gökhan⁹³^ORCID,Zenoaga-Barbăroşie Cătălina¹⁹⁴^ORCID,Barrett Trenton L.¹⁹⁵^ORCID,Yilmaz Mehmet¹⁹⁶^ORCID,Kadioglu Ates¹⁹⁷^ORCID,Jindal Sunil¹⁹⁸^ORCID,Omran Huda¹⁹⁹^ORCID,Bocu Kadir¹¹⁰⁰^ORCID,Karthikeyan Vilvapathy Senguttuvan¹¹⁰¹^ORCID,Franco Giorgio¹¹⁰²^ORCID,Solorzano Jesús Fernando¹⁶⁰^ORCID,Vishwakarma Ranjit B.¹¹⁰³^ORCID,Arianto Eko¹¹⁰⁴^ORCID,Garrido Nicolas¹¹⁰⁵^ORCID,Jain Divyanu¹¹⁰⁶^ORCID,Gherabi Nazim¹¹⁰⁷^ORCID,Sokolakis Ioannis¹¹⁰⁸^ORCID,Palani Ayad¹¹⁰⁹^ORCID,Calik Gokhan¹⁷⁹^ORCID,Kulaksiz Deniz¹¹¹⁰^ORCID,Simanaviciene Vaida¹¹¹¹^ORCID,Simopoulou Mara¹¹¹²^ORCID,Güngör Nur Dokuzeylül¹¹¹³^ORCID,Blecher Gideon¹¹¹⁴^ORCID,Falcone Marco¹¹¹⁵^ORCID,Jezek Davor¹¹¹⁶^ORCID,Preto Mirko¹¹¹⁵^ORCID,Amar Edouard¹¹¹⁷^ORCID,Le Tan V.¹²²²³^ORCID,Ahn Sun Tae¹¹¹⁸^ORCID,Rezano Andri¹¹¹⁹^ORCID,Singh Keerti¹¹²⁰^ORCID,Rocco Lucia¹¹²¹^ORCID,Savira Missy¹¹⁹^ORCID,Rajmil Osvaldo¹¹²²^ORCID,Darbandi Sara¹⁷⁵⁷⁶^ORCID,Sogutdelen Emrullah¹¹²³^ORCID,Boeri Luca¹¹²⁴^ORCID,Hernández Guadalupe¹¹²⁵^ORCID,Hakim Lukman¹¹²⁶^ORCID,Morimoto Yoshiharu¹¹²⁷^ORCID,Japari Andrian¹¹²⁸^ORCID,Sofikitis Nikolaos¹¹²⁹^ORCID,Altay Baris¹¹³⁰^ORCID,Metin Mahmutoglu Asli¹¹³¹^ORCID,Al Hashimi Manaf¹¹³²^ORCID,Ziouziou Imad¹¹³³^ORCID,Anagnostopoulou Christina¹¹³⁴^ORCID,Lin Haocheng¹¹³⁵^ORCID,Shah Rupin¹¹⁰³^ORCID

Affiliation:

1. Global Andrology Forum, Moreland Hills, OH, USA.

2. Cleveland Clinic, Cleveland, OH, USA.

3. Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.

4. Department of Urology, King Abdulaziz University, Jeddah, Saudi Arabia.

5. Department of Urology, Faculty of Medicine, Minia University, Minia, Egypt.

6. Department of Endocrinology, Polytechnic University of Marche, Ancona, Italy.

7. Reproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France.

8. Department of Biology, Reproduction, Epigenetics, Environment, and Development, Paris Saclay University, UVSQ, INRAE, BREED, Jouy-en-Josas, France.

9. Urology and Nephrology Center, Mansoura, Egypt.

10. Department of Surgery, Urology Unit, Farwaniya Hospital, Farwaniya, Kuwait.

11. Department of Urology, Sabah Al Ahmad Urology Center, Kuwait City, Kuwait.

12. Urology Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, USA.

13. Department of Reproductive Urology, Austin Fertility & Reproductive Medicine/Westlake IVF, Austin, TX, USA.

14. Department of Urology, SelÃ§uk University School of Medicine, Konya, Turkey.

15. Department of Urology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

16. Urology Section, University of Catania, Catania, Italy.

17. Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia.

18. Department of Urology, Henry Ford Health System, Vattikuti Urology Institute, Detroit, MI, USA.

19. Department of Urology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

20. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

21. Department of Urology, Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

22. Department of Andrology, Binh Dan Hospital, Ho Chi Minh City, Vietnam.

23. Department of Urology and Andrology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.

24. Department of Surgery, McGill University, Montreal, QC, Canada.

25. Department of Urology, Hamad Medical Corporation, Doha, Qatar.

26. Department of Urology, Weill Cornell Medical-Qatar, Doha, Qatar.

27. Department of Andrology and STDs, Cairo University, Cairo, Egypt.

28. Department of Gynaecology-Andrology, Cliniques Universitaires Saint-Luc, Universitat Catholique de Louvain, Brussels, Belgium.

29. Department of Obstetrics Gynaecology and Reproductive Medicine, Flinders University, Bedford Park, Australia.

30. Department of Urology, Galhane Research and Training Hospital, University of Health Sciences, Ankara, Turkey.

31. Examen Lab Ltd., Northern Ireland, UK.

32. SCSA Diagnostics, Brookings, SD, USA.

33. Department of Urology, Loma Linda University Health, Loma Linda, CA, USA.

34. Andrology Section, Siloam Sriwijaya Hospital, Palembang, Indonesia.

35. Section of Urology, Department of Surgery, University of Santo Tomas Hospital, Manila, Philippines.

36. Department of Urology, Centro Universitario em Saude do ABC, Santo Andre, Brazil.

37. Andrology Group at Ideia Fertil Institute of Human Reproduction, Santo Andre, Brazil.

38. Andrology and IVF Center, Next Fertility Procrea, Lugano, Switzerland.

39. SENSART Clinic, Urology, Fulya, Istanbul, Turkey.

40. Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

41. Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa.

42. Fakih IVF Fertility Center, Abu Dhabi, UAE.

43. Department of Urology, Biruni University School of Medicine, Istanbul, Turkey.

44. Department of Urology, King Fahad Medical City, Riyadh, Saudi Arabia.

45. Department of Urology, Juntendo University Urayasu Hospital, Chiba, Japan.

46. Department of Urology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

47. Reproductive Medicine Unit, ANDROS Day Surgery Clinic, Reproductive Medicine Unit, Palermo, Italy.

48. IVF Department, Astghik Medical Center, Yerevan, Armenia.

49. Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

50. Department of Urology, Faculty of Medicine, Baskent University, Ankara, Turkey.

51. Andrology and Reproductive Medicine Unit, Gynepro Medical, Bologna, Italy.

52. Andromed Health & Reproduction, Fertility & Reproductive Health Diagnostic Center, Athens, Greece.

53. Department of Urology and Renal Transplantation, University of Foggia, Policlinico Riuniti, Foggia, Italy.

54. Department of Urology, College of Medicine, Qatar University, Doha, Qatar.

55. Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

56. Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

57. Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.

58. Department of Urology, Pusan National University School of Medicine, Busan, Korea.

59. Medical Research Institute of Pusan National University Hospital, Busan, Korea.

60. IVF Laboratory, CITMER Reproductive Medicine, Mexico City, Mexico.

61. Division of Urology, Department of Surgery, Sultan Qaboos University, Muscat, Sultanate of Oman.

62. King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

63. Center for Andrology and Sexual Medicine, Viet Duc University Hospital, Hanoi, Vietnam.

64. Department of Urology, Andrology and Sexual Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.

65. Department of Urology, Innsbruck Medical University, Innsbruck, Austria.

66. Department of Urology, Topiwala National Medical College, B.Y.L Nair Ch Hospital, Mumbai, India.

67. Department of Andrology, Uromedica Polyclinic, Belgrade, Serbia.

68. Department of Biosciences, University of Kent, Canterbury, UK.

69. Department of Obstetrics and Gynecology, Hanoi Obstetric and Gynecology Hospital, Hanoi, Vietnam.

70. Department of Surgery, School of Medicine, Taylor’s University, Subang Jaya, Selangor, Malaysia.

71. Division of Urology, Department of Surgery, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

72. Department of Urology, University of Queensland, Princess Alexandra Hospital, Brisbane QLD, Australia.

73. IVF Michigan, Bloomfield Hills, MI, USA.

74. Department of Urology, Konya City Hospital, Konya, Turkey.

75. Fetal Health Research Center, Hope Generation Foundation, Tehran, Iran.

76. Gene Therapy and Regenerative Medicine Research Center, Hope Generation Foundation, Tehran, Iran.

77. Department of Urology, Graduate School of Medicine, Osaka University, Osaka, Japan.

78. Department of Urology, Mohammed V Military Hospital, Rabat, Morocco.

79. Department of Urology, Istanbul Medipol University, Istanbul, Turkey.

80. Department of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA.

81. Department of Urology, Bandirma Onyedi Eylül University, Balikesir, Turkey.

82. Department of Urology, Taksim Education and Research Hospital, Istanbul, Turkey.

83. Division of Urology, Southern Illinois University, Springfield, IL, USA.

84. Department of Urology, Ankara University, Ankara, Turkey.

85. Androlab, Fertility Clinic, Curitiba, PR, Brazil.

86. Department of Urology, University of Texas McGovern Medical School, Houston, TX, USA.

87. Department of Urology, MD Anderson Cancer Center, Houston, TX, USA.

88. Department of Urology, SCM Clinic and Hospital, New Delhi, India.

89. Department of Urology, Lebanese University, Beirut, Lebanon.

90. Department of Urology, Al Zahraa Hospital, UMC, Lebanon.

91. Department of Biological Sciences, University of Toledo, Toledo, OH, USA.

92. Department of Urology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.

93. Department of Urology, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey.

94. Department of Genetics, Faculty of Biology, University of Bucharest, Bucharest, Romania.

95. Department of Urology, Perth Urology Clinic, Murdoch, WA, Australia.

96. Asklepios Klinik Triberg, Urology, Triberg, Germany.

97. Section of Andrology, Department of Urology, Istanbul University, Istanbul, Turkey.

98. Department of Andrology and Reproductive Medicine, Jindal Hospital, Meerut, India.

99. Molecular Genetics Department, Pulse Health Training Center, Manama, Bahrain.

100. Department of Urology, Silopi State Hospital, Sirnak, Turkey.

101. Andrology Unit, Department of Urology, Apollo Hospitals, Greams Road, Chennai, India.

102. Department of Urology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

103. Division of Andrology, Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India.

104. Department of Surgery, Prof. Dr. R.D. Kandou Central General Hospital, Manado, Indonesia.

105. IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.

106. Department of Obstetrics and Gynecology, Jaipur Golden Hospital, New Delhi, India.

107. Department of Medicine, University of Algiers 1, Algiers, Algeria.

108. 2nd Department of Urology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

109. Research Centre, University of Garmian, Kalar, Iraq.

110. Department of Obstetrics and Gynecology, University of Health Sciences Kanuni Training and Research Hospital, Trabzon, Turkey.

111. Fertility Centre, Northway Medical Centre, Vilnius, Lithuania.

112. Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

113. Department of Obstetrics and Gynecology, Reproductive Endocrinology and IVF Unit, School of Medicine, Bahcesehir University, Istanbul, Turkey.

114. Department of Surgery, School of Clinical Sciences, Monash University, Melbourne, Australia.

115. Department of Urology, Molinette Hospital, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, University of Turin, Torino, Italy.

116. Reproductive Tissue Bank, Department for Transfusion Medicine and Transplantation Biology, University Hospital Zagreb, Zagreb, Croatia.

117. American Hospital of Paris, Paris, France.

118. Department of Urology, Korea University College of Medicine, Seoul, Korea.

119. Department of Biomedical Sciences, Division of Cell Biology, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia.

120. Department of Preclinical and Health Sciences, Faculty of Medical Sciences, The University of the West Indies, Cave Hill Campus, St Michael, Barbados, Italy.

121. Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Caserta, Italy.

122. Department of Andrology, Fundacio Puigvert, Barcelona, Spain.

123. Department of Urology, Bolu Abant Izzet Baysal University, Bolu, Turkey.

124. Department of Urology, IRCCS Fondazione Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy.

125. IVF Department, CITMER Reproductive Medicine, Puebla, Mexico.

126. Department of Urology, Faculty of Medicine, Universitas Airlangga Teaching Hospital, Surabaya, Indonesia.

127. Department of Urology, HORAC Grand Front Osaka Clinic, Osaka, Japan.

128. Department of Urology, Fertility Clinic, Telogorejo Hospital, Central Java, Indonesia.

129. Department of Urology, Ioannina University School of Medicine, Ioannina, Greece.

130. Department of Urology, Ege University, Izmir, Turkey.

131. Departmant of Medical Biology, Faculty of Medical, Yozgat Bozok University, Yozgat, Turkey.

132. Department of Urology, Burjeel Hospital, Abu Dhabi, UAE.

133. Department of Urology, University Hospital of Souss Massa, Massa, Morocco.

134. Unit of Reproductive Medicine, EmbryoART, Leto Maternity Hospital, Athens, Greece.

135. Department of Urology, Peking University Third Hospital, Beijing, China.

Publisher

XMLink

Subject

Pharmacology (medical),Urology,Psychiatry and Mental health,Public Health, Environmental and Occupational Health,Health Policy,Aging,Reproductive Medicine

Link

https://wjmh.org/pdf/10.5534/wjmh.230076

Reference37 articles.

1. Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality

2. Types, Causes, Detection and Repair of DNA Fragmentation in Animal and Human Sperm Cells

3. Sperm DNA Fragmentation: A New Guideline for Clinicians

4. Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines

5. Insight into oxidative stress in varicocele-associated male infertility: part 1

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