Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations-Reference-Cited by-同舟云学术

Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations

Published:2023 Issue:3 Volume:41 Page:575
ISSN:2287-4208
Container-title:The World Journal of Men's Health
language:en
Short-container-title:World J Mens Health

Author:

Agarwal Ashok¹²^ORCID,Farkouh Ala’a¹^ORCID,Saleh Ramadan³^ORCID,Abdel-Meguid Hamoda Taha Abo-Almagd⁴⁵^ORCID,Harraz Ahmed M.⁶⁷⁸^ORCID,Kavoussi Parviz⁹^ORCID,Arafa Mohamed¹⁰¹¹¹²^ORCID,Salvio Gianmaria¹³^ORCID,Rambhatla Amarnath¹⁴^ORCID,Toprak Tuncay¹⁵^ORCID,Gül Murat¹⁶^ORCID,Phuoc Nguyen Ho Vinh¹⁷¹⁸^ORCID,Boitrelle Florence¹⁹²⁰^ORCID,Birowo Ponco²¹^ORCID,Ghayda Ramy Abou²²^ORCID,Cannarella Rossella²³^ORCID,Kuroda Shinnosuke²⁴^ORCID,Durairajanayagam Damayanthi²⁵^ORCID,Zini Armand²⁶^ORCID,Wyns Christine²⁷^ORCID,Sarikaya Selcuk²⁸^ORCID,Tremellen Kelton²⁹^ORCID,Mostafa Taymour¹²^ORCID,Sokolakis Ioannis³⁰^ORCID,Evenson Donald P.³¹^ORCID,Henkel Ralf³²³³³⁴^ORCID,Zohdy Wael¹²^ORCID,Chung Eric³⁵^ORCID,Ziouziou Imad³⁶^ORCID,Falcone Marco³⁷^ORCID,Russo Giorgio I.³⁸^ORCID,Al-Hashimi Manaf³⁹⁴⁰^ORCID,Calogero Aldo E.²³^ORCID,Ko Edmund⁴¹^ORCID,Colpi Giovanni⁴²^ORCID,Lewis Sheena⁴³^ORCID,Serefoglu Ege Can⁴⁴^ORCID,Bahar Fahmi⁴⁵^ORCID,Martinez Marlon⁴⁶^ORCID,Nguyen Quang⁴⁷⁴⁸^ORCID,Ambar Rafael F.⁴⁹⁵⁰^ORCID,Bakircioglu Mustafa Emre⁵¹^ORCID,Kandil Hussein⁵²^ORCID,Mogharabian Nasser⁵³^ORCID,Sabbaghian Marjan⁵⁴^ORCID,Taniguchi Hisanori⁵⁵^ORCID,Tsujimura Akira⁵⁶^ORCID,Sajadi Hesamoddin⁵⁴^ORCID,Ibrahim Wael⁵⁷^ORCID,Atmoko Widi²¹^ORCID,Vogiatzi Paraskevi⁵⁸^ORCID,Gunes Sezgin⁵⁹^ORCID,Gilani Mohammad Ali Sadighi⁵⁴^ORCID,Roychoudhury Shubhadeep⁶⁰^ORCID,Güngör Nur Dokuzeylül⁶¹^ORCID,Hakim Lukman⁶²^ORCID,Adriansjah Ricky⁶³^ORCID,Kothari Priyank⁶⁴^ORCID,Jindal Sunil⁶⁵^ORCID,Amar Edouard⁶⁶^ORCID,Park Hyun Jun⁶⁷⁶⁸^ORCID,Long Tran Quang Tien⁶⁹^ORCID,Homa Sheryl⁷⁰^ORCID,Karthikeyan Vilvapathy Senguttuvan⁷¹^ORCID,Zilaitiene Birute⁷²^ORCID,Rosas Israel Maldonado⁷³^ORCID,Marino Angelo⁷⁴^ORCID,Pescatori Edoardo⁷⁵^ORCID,Ozer Cevahir⁷⁶^ORCID,Akhavizadegan Hamed⁷⁷^ORCID,Garrido Nicolas⁷⁸^ORCID,Busetto Gian Maria⁷⁹^ORCID,Adamyan Aram⁸⁰^ORCID,Al-Marhoon Mohamed⁸¹^ORCID,Elbardisi Haitham¹⁰¹¹^ORCID,Dolati Parisa⁸²^ORCID,Darbandi Mahsa⁸³⁸⁴^ORCID,Darbandi Sara⁸³⁸⁴^ORCID,Balercia Giancarlo¹³^ORCID,Pinggera Germar-Michael⁸⁵^ORCID,Micic Sava⁸⁶^ORCID,Ho Christopher Chee Kong⁸⁷^ORCID,Moussa Mohamad⁸⁸⁸⁹^ORCID,Preto Mirko³⁷^ORCID,Zenoaga-Barbăroşie Cătălina⁹⁰^ORCID,Smith Ryan P.⁹¹^ORCID,Kosgi Raghavender⁹²^ORCID,Rosette Jean de la⁹³^ORCID,El-Sakka Ahmed I.⁹⁴^ORCID,Abumelha Saad Mohammed⁹⁵^ORCID,Mierzwa Tiago Cesar⁹⁶^ORCID,Ong Teng Aik⁹⁷^ORCID,Banihani Saleem A.⁹⁸^ORCID,Bowa Kasonde⁹⁹^ORCID,Fukuhara Shinichiro¹⁰⁰^ORCID,Boeri Luca¹⁰¹^ORCID,Danacıoğlu Yavuz Onur¹⁰²^ORCID,Gokalp Fatih¹⁰³^ORCID,Selim Osama Mohamed¹²^ORCID,Cho Chak-Lam¹⁰⁴^ORCID,Tadros Nicholas N.¹⁰⁵^ORCID,Ugur Muhammet Rasit¹⁰⁶^ORCID,Ozkent Mehmet Serkan¹⁰⁷^ORCID,Chiu Peter¹⁰⁴^ORCID,Kalkanli Arif¹⁰⁸^ORCID,Khalafalla Kareim¹⁰¹⁰⁹^ORCID,Vishwakarma Ranjit B.¹¹⁰^ORCID,Finocchi Federica¹³¹¹¹^ORCID,Andreadakis Sotiris¹¹²^ORCID,Giulioni Carlo¹¹³^ORCID,Çeker Gökhan¹¹⁴¹¹⁵^ORCID,Ceyhan Erman⁷⁶^ORCID,Malhotra Vineet¹¹⁶^ORCID,Yilmaz Mehmet¹¹⁷^ORCID,Timpano Massimiliano³⁷^ORCID,Barrett Trenton L.¹¹⁸^ORCID,Kim Shannon Hee Kyung¹¹⁹¹²⁰^ORCID,Ahn Sun-Tae¹²¹^ORCID,Giacone Filippo¹²²^ORCID,Palani Ayad¹²³^ORCID,Duarsa Gede Wirya Kusuma¹²⁴^ORCID,Kadioglu Ates¹²⁵^ORCID,Gadda Franco¹⁰¹^ORCID,Zylbersztejn Daniel Suslik¹²⁶^ORCID,Aydos Kaan¹²⁷^ORCID,Kulaksız Deniz¹²⁸^ORCID,Gupte Deepak¹²⁹^ORCID,Calik Gokhan¹³⁰^ORCID,Karna Keshab Kumar¹³¹^ORCID,Drakopoulos Panagiotis¹³²¹³³^ORCID,Baser Aykut¹³⁴^ORCID,Kumar Vijay¹³⁵^ORCID,Molina Juan Manuel Corral¹³⁶^ORCID,Rajmil Osvaldo¹³⁷^ORCID,Ferreira Raphael H.¹³⁸^ORCID,Leonardi Sofia¹³⁹^ORCID,Avoyan Armen¹⁴⁰^ORCID,Sogutdelen Emrullah¹⁴¹^ORCID,Franco Giorgio¹⁴²^ORCID,Ramsay Jonathan¹⁴³^ORCID,Ramirez Liliana⁷³^ORCID,Shah Rupin¹¹⁰^ORCID,

Affiliation:

1. Global Andrology Forum, American Center for Reproductive Medicine, Moreland Hills, OH, USA.

2. Cleveland Clinic Foundation, Cleveland, OH, USA.

3. Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.

4. Department of Urology, King Abdulaziz University, Jeddah, Saudi Arabia.

5. Department of Urology, Faculty of Medicine, Minia University, Minia, Egypt.

6. Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

7. Department of Surgery, Urology Unit, Farwaniya Hospital, Farwaniya, Kuwait.

8. Department of Urology, Sabah Al Ahmad Urology Center, Kuwait City, Kuwait.

9. Department of Reproductive Urology, Austin Fertility & Reproductive Medicine/Westlake IVF, Austin, TX, USA.

10. Department of Urology, Hamad Medical Corporation, Doha, Qatar.

11. Department of Urology, Weill Cornell Medical-Qatar, Doha, Qatar.

12. Department of Andrology, Sexology and STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.

13. Department of Endocrinology, Polytechnic University of Marche, Ancona, Italy.

14. Department of Urology, Henry Ford Health System, Vattikuti Urology Institute, Detroit, MI, USA.

15. Department of Urology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

16. Department of Urology, Selçuk School of Medicine, Konya, Turkey.

17. Department of Andrology, Binh Dan Hospital, Ho Chi Minh City, Vietnam.

18. Department of Urology and Andrology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.

19. Reproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France.

20. Department of Biology, Reproduction, Epigenetics, Environment and Development, Paris Saclay University, UVSQ, INRAE, BREED, Jouy-en-Josas, France.

21. Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

22. Urology Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, USA.

23. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

24. Department of Urology, Cleveland Clinic, Cleveland, OH, USA.

25. Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia.

26. Department of Surgery, McGill University, Montreal, QC, Canada.

27. Department of Gynaecology-Andrology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

28. Department of Urology, Gülhane Research and Training Hospital, University of Health Sciences, Ankara, Turkey.

29. Department of Obstetrics Gynaecology and Reproductive Medicine, Flinders University, Bedford Park, Australia.

30. Department of Urology, Martha-Maria Hospital Nuremberg, Nuremberg, Germany.

31. SCSA Diagnostics, Brookings, SD, USA.

32. Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

33. Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa.

34. LogixX Pharma, Theale, Berkshire, UK.

35. Department of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia.

36. Department of Urology, College of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco.

37. Department of Urology, Molinette Hospital, A.O.U. Città della Salute e della Scienza, University of Turin, Torino, Italy.

38. Urology Section, University of Catania, Catania, Italy.

39. Department of Urology, Burjeel Hospital, Abu Dhabi, UAE.

40. Department of Urology, Clinical Urology, Khalifa University, College of Medicine and Health Sciences, Abu Dhabi, UAE.

41. Department of Urology, Loma Linda University Health, Loma Linda, CA, USA.

42. Andrology and IVF Center, Next Fertility Procrea, Lugano, Switzerland.

43. Examen Lab Ltd., Northern Ireland, UK.

44. Department of Urology, Biruni University School of Medicine, Istanbul, Turkey.

45. Andrology Section, Siloam Sriwijaya Hospital, Palembang, Indonesia.

46. Section of Urology, Department of Surgery, University of Santo Tomas Hospital, Manila, Philippines.

47. Center for Andrology and Sexual Medicine, Viet Duc University Hospital, Hanoi, Vietnam.

48. Department of Urology, Andrology and Sexual Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.

49. Department of Urology, Centro Universitario em Saude do ABC, Santo André, Brazil.

50. Andrology Group at Ideia Fertil Institute of Human Reproduction, Santo André, Brazil.

51. SENSART Clinic, Urology, Fulya, Istanbul, Turkiye.

52. Fakih IVF Fertility Center, Abu Dhabi, UAE.

53. Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.

54. Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

55. Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.

56. Department of Urology, Juntendo University Urayasu Hospital, Chiba, Japan.

57. Department of Obstetrics Gynaecology and Reproductive Medicine, Fertility Care Center in Cairo, Cairo, Egypt.

58. Andromed Health & Reproduction, Fertility & Reproductive Health Diagnostic Center, Athens, Greece.

59. Department of Medical Biology, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey.

60. Department of Life Science and Bioinformatics, Assam University, Silchar, India.

61. Department of Obstetrics and Gynecology, Reproductive Endocrinology and IVF Unit, School of Medicine, Bahcesehir University, Istanbul, Turkey.

62. Department of Urology, Faculty of Medicine Universitas Airlangga, Universitas Airlangga Teaching Hospital, Surabaya, Indonesia.

63. Department of Urology, Faculty of Medicine Universitas Padjajaran, Hasan Sadikin General Hospital, Bandung, Indonesia.

64. Department of Urology, Topiwala National Medical College, B.Y.L Nair Ch Hospital, Mumbai, India.

65. Department of Andrology and Reproductive Medicine, Jindal Hospital, Meerut, India.

66. Department of Urology, American Hospital of Paris, Paris, France.

67. Department of Urology, Pusan National University School of Medicine, Busan, Korea.

68. Medical Research Institute of Pusan National University Hospital, Busan, Korea.

69. Department of Obstetrics and Gynecology, Hanoi Obstetric and Gynecology Hospital, Hanoi, Vietnam.

70. Department of Biosciences, University of Kent, Canterbury, UK.

71. Andrology Unit, Department of Urology, Apollo Hospitals, Greams Road, Chennai, India.

72. Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

73. IVF Laboratory, CITMER Reproductive Medicine, Mexico City, Mexico.

74. Reproductive Medicine Unit, ANDROS Day Surgery Clinic, Palermo, Italy.

75. Andrology and Reproductive Medicine Unit, Gynepro Medical, Bologna, Italy.

76. Department of Urology, Faculty of Medicine, Baskent University, Ankara, Turkey.

77. Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

78. IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.

79. Department of Urology and Renal Transplantation, University of Foggia, Policlinico Riuniti, Foggia, Italy.

80. IVF Department, Astghik Medical Center, Yerevan, Armenia.

81. Division of Urology, Department of Surgery, Sultan Qaboos University, Muscat, Sultanate of Oman.

82. Department of Animal Science, Faculty of Agriculture, University of Shiraz, Iran.

83. Fetal Health Research Center, Hope Generation Foundation, Tehran, Iran.

84. Gene Therapy and Regenerative Medicine Research Center, Hope Generation Foundation, Tehran, Iran.

85. Department of Urology, Innsbruck Medical University, Innsbruck, Austria.

86. Department of Andrology, Uromedica Polyclinic, Belgrade, Serbia.

87. Department of Surgery, School of Medicine, Taylor's University, Subang Jaya, Selangor, Malaysia.

88. Department of Urology, Lebanese University, Beirut, Lebanon.

89. Department of Urology, Al Zahraa Hospital, UMC, Lebanon.

90. Department of Genetics, Faculty of Biology, University of Bucharest, Bucharest, Romania.

91. Department of Urology, University of Virginia School of Medicine, Virginia, USA.

92. Department of Urology, Andrology and Renal Transplant, AIG Hospitals, Hyderabad, India.

93. Department of Urology, Istanbul Medipol Mega University Hospital, Istanbul, Turkey.

94. Department of Urology, Suez Canal University, Ismailia, Egypt.

95. Division of Urology, Department of Surgery, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

96. Androlab, Fertility Clinic, Curitiba, PR, Brazil.

97. Department of Surgery, University of Malaya, Kuala Lumpur, Malaysia.

98. Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan.

99. Department of Urology, University of Lusaka, Lusaka, Zambia.

100. Department of Urology, Graduate School of Medicine, Osaka University, Osaka, Japan.

101. Department of Urology, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

102. Department of Urology, University of Health Science Istanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

103. Department of Urology, Hatay Mustafa Kemal University, Antakya, Turkey.

104. S. H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong.

105. Division of Urology, Southern Illinois University, Springfield, IL, USA.

106. IVF Michigan, Bloomfield Hills, MI, USA.

107. Department of Urology, Konya City Hospital, Konya, Turkey.

108. Department of Urology, Taksim Education and Research Hospital, Istanbul, Turkey.

109. Department of Urology, University of Illinois, Chicago, IL, USA.

110. Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India.

111. Unit of Andrology and Reproductive Medicine, University of Padua, Padua, Italy.

112. Private Practice, Thessaloniki, Greece.

113. Department of Urology, Polytechnic University of Marche Region, Ancona, Italy.

114. Department of Urology, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey.

115. Department of Embryology and Histology, Zonguldak Bülent Ecevit University Institute of Health Sciences, Zonguldak, Turkey.

116. Department of Urology, SCM Clinic and Hospital, New Delhi, India.

117. Department of Urology, Faculty of Medicine, University of Freiburg-Medical Centre, Freiburg, Germany.

118. Perth Urology Clinic, Perth, WA, Australia.

119. IVF Australia, Sydney, Australia.

120. Macquarie School of Medicine, Macquaire University, Sydney, Australia.

121. Department of Urology, Korea University College of Medicine, Seoul, Korea.

122. Centro HERA, Unità di Medicina della Riproduzione, Sant'Agata Li Battiati, Catania, Italy.

123. Research Centre, University of Garmian, Kalar, Iraq.

124. Department of Urology, Udayana University, Denpasar, Indonesia.

125. Section of Andrology, Department of Urology, Istanbul University, Istanbul, Turkey.

126. Fleury Group and Hospital Israelita Albert Einstein, São Paulo, Brazil.

127. Department of Urology, Ankara University, Ankara, Turkey.

128. Department of Obstetrics and Gynecology, University of Health Sciences Kanuni Training and Research Hospital, Trabzon, Turkey.

129. Department of Urology, Bombay Hospital and Medical Research Center, Mumbai, India.

130. Department of Urology, Istanbul Medipol University, Istanbul, Turkey.

131. Department of Molecular Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.

132. Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

133. IVF Athens, Athens, Greece.

134. Department of Urology, Bandirma Onyedi Eylül University, Balikesir, Turkey.

135. Department of Microbiology, Kurukshetra University, Kurukshetra, India.

136. Urology Department, Hospital Clinic of Barcelona, Barcelona, Spain.

137. Department of Andrology, Fundacio Puigvert, Barcelona, Spain.

138. Department of Urology, Santa Casa de Ribeirão Preto, São Paulo, Brazil.

139. Central Laboratory, Hospital Publico Materno Infantil de Salta, Salta, Argentina.

140. Urology Department, Astghik Medical Center, Yerevan, Armenia.

141. Department of Urology, Bolu Abant Izzet Baysal University, Bolu, Turkey.

142. Department of Urology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

143. Department of Andrology, Hammersmith Hospital, London, UK.

Publisher

XMLink

Subject

Pharmacology (medical),Urology,Psychiatry and Mental health,Public Health, Environmental and Occupational Health,Health Policy,Aging,Reproductive Medicine

Link

https://wjmh.org/pdf/10.5534/wjmh.220282

Reference73 articles.

1. Sperm DNA damage and its impact on male reproductive health: a critical review for clinicians, reproductive professionals and researchers

2. Apoptosis spermatogenesis and male infertility

3. Sperm DNA Fragmentation: Mechanisms of Origin

4. Structure of Chromatin in Spermatozoa

5. Reactive oxygen species impact on sperm DNA and its role in male infertility

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