Regenerative treatment of spinal cord injury. Literature review. Part 4

Abstract

Treating traumatic spinal cord injuries is one of the most complicated and relevant problems in the modern medicine. In the vast majority of cases spinal cord injury (SCI) leads to persistent disability, with medical, social and economic consequences ensuing for the patient, the family and the state. Modern SCI therapy has a very limited effectiveness and does not allow to sufficiently restore the lost functions of central nervous system. Regenerative methods and particularly cell therapy are very promising to effectively treat SCI. The review highlights SCI epidemiological and pathogenetic problems, existing therapy, as well as promising methods of regenerative therapy. We emphasize the results of preclinical and clinical studies in the field of cell therapy. The review is divided into 4 parts. In part 4, the use of human cord blood cells in SCI is discussed, in particular, the advantages of this type of therapy are considered, the composition of the cord blood cell mixture is described, and the results of preclinical and clinical studies are reported.