The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancer

Author:

Kovalenko T. A.1,Panteleev M. A.2ORCID,Sveshnikova A. N.3ORCID

Affiliation:

1. Lomonosov Moscow State University; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences

2. Lomonosov Moscow State University; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia;

3. Lomonosov Moscow State University; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia;

Abstract

Tissue factor, being the main initiator of the blood coagulation in vivo, is involved in a number of physiological processes, such as angiogenesis or cell migration. These processes are not only significant for normal physiology, but also play a role in the development and progression of oncological diseases. This review presents data on the structure of tissue factor, its expression in normal conditions and in cancer, its role in thrombosis development associated with cancer, in angiogenesis and in metastasis. The involvement of tissue factor in such a wide range of physiological processes important for the progression of cancer makes it an attractive target molecule for therapy.

Publisher

Publishing House ABV Press

Subject

Oncology,Hematology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Role of Platelet Activation in the Development and Metastasis of Solid Tumors;Российский физиологический журнал им  И  М  Сеченова;2024-06-28

2. Dissecting thrombus-directed chemotaxis and random movement in neutrophil near-thrombus motion in flow chambers;BMC Biology;2024-05-20

3. Role of Platelet Activation in the Development and Metastasis of Solid Tumors;Journal of Evolutionary Biochemistry and Physiology;2024-01

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3