Effect of aromatase inhibitors on male fertility: literature review

Abstract

Aсcording to the Russian Society of Urology the incidence of infertile couples ranges from 8 to 17.2 % in various regions of Russia, while the male factor accounts for about half of all cases, which requires a balanced approach to diagnosing the causes of reduced fertility and selecting personalized therapy. In accordance with the Russian Society of Urology guidelines, gonadotropins, selective estrogen receptor modulators and antioxidants can be used in the treatment of male infertility. According to the European Association of Urologists guidelines and American Urological Association/ American Society for Reproductive Medicine guidelines, this list may also include gonadotropin-releasing hormone and aromatase inhibitors (AI).Research objective: to review up-to-date literature data on effect of IA on male fertility and clarify the place of AI in the treatment of male infertility.The data obtained indicate that AI can increase the concentration, mobility and percentage of normal forms of spermatozoa, reduce sperm DNA fragmentation and normalize protamination processes. These effects were more pronounced in patients with overweight and obesity, as well as in patients with testosterone-to-estradiol ratios of <10. Given the important role of estrogens in spermatogenesis, when using AI, it is advisable to control the hormonal status and prevent estradiol from falling below the reference range, taking into account its multiple effects. However, a lack of quality data causes inability to accurately predict the effect of AI treatment on pregnancy rate and childbirth. Further research is required to formulate recommendations based on evidence for the use of AI for treatment of male infertility, in Russia changes in the instructions for medicines and regulatory documents will be required.