次世代シークエンスを用いて検出したEGFR mutation L747P肺腺癌の1例
Author:
Affiliation:
1. Division of Pulmonary Medicine, Department of Internal Medicine, The Iwate University School of Medicine
2. Division of Respiratory Surgery, The Iwate University School of Medicine
Publisher
Japanese Society of Internal Medicine
Subject
General Medicine
Link
https://www.jstage.jst.go.jp/article/naika/112/1/112_77/_pdf
Reference9 articles.
1. 1) Kouya Shiraishi, et al: Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. Nat Commun 7: 12451, 2016.
2. 2) 肺癌患者におけるEGFR遺伝子変異検査の手引き 第5.0版. 日本肺癌学会バイオマーカー委員会編, 2021.
3. 3) James C-H Yang, et al: Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6. Lancet Oncol 16 (7): 830-838, 2015.
4. 4) Takahiro Yoshizawa, et al: Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity. npj Precision Oncology 5: 32, 2021.
5. 5) 西山和宏, 他: PCR陰性であったがNGSで診断し得たEGFR exon19欠失挿入変異陽性肺腺癌の1例. 肺癌 61: 143-144, 2021
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