Boron neutron capture therapy (BNCT) for newly-diagnosed glioblastoma: Comparison of clinical results obtained with BNCT and conventional treatment

Author:

Kageji Teruyoshi1,Nagahiro Shinji1,Mizobuchi Yoshifumi1,Matsuzaki Kazuhito2,Nakagawa Yoshinobu3,Kumada Hiroaki4

Affiliation:

1. Department of Neurosurgery, School of Medicine, the University of Tokushima

2. Department of Neurosurgery, Tokushima Prefectural Central Hospital

3. Department of Neurosurgery, Shikoku Medical Center for Children and Adults

4. Department of Radiation Oncology, Graduate School of Comprehensive Human Science, University of Tsukuba

Publisher

University of Tokushima Faculty of Medicine

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference31 articles.

1. 1. Athanassiou H, Synodinou M, Maragoudakis E, Paraskevaidis M, Verigos C, Misailidou D, Antonnadou D, Saris G, Beroukas K, Karageorgis P: Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme. J Clin Oncol 23: 2372-2377, 2005

2. 2. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO for the European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups and the National Cancer Institute of Canada Clinical Trial Group: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Eng J Med 352: 987-996, 2005

3. 3. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJB, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial: Lancet Oncol 10: 459-466, 2009

4. 4. Locher GL: Biological effects and therapeutic possibilities of neutron. Am J Roentgenol 36: 1-13, 1936

5. 5. Hatanaka, H: Introduction. In: Hatanaka H, editor. Boron Neutron Capture Therapy for Tumors. Niigata: Nishimura: p. 1-28, 1986

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