CEST and PARACEST MR contrast agents-Reference-Cited by-同舟云学术

CEST and PARACEST MR contrast agents

Published:2010-10 Issue:8 Volume:51 Page:910-923
ISSN:0284-1851
Container-title:Acta Radiologica
language:en
Short-container-title:Acta Radiol

Author:

Hancu Ileana¹,Dixon W. Thomas¹,Woods Mark²,Vinogradov Elena³,Sherry A. Dean²⁴,Lenkinski Robert E.³

Affiliation:

1. GE Global Research Center, Niskayuna, NY, USA

2. University of Texas at Dallas, Dallas, TX, USA

3. Beth Israel Deaconess Medical Center, Boston, MA, USA

4. University of Texas Southwestern Medical Center, Dallas, TX, USA

Abstract

In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.

Publisher

SAGE Publications

Subject

Radiology, Nuclear Medicine and imaging,General Medicine,Radiological and Ultrasound Technology

Link

http://journals.sagepub.com/doi/pdf/10.3109/02841851.2010.502126

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