Abstract
AbstractIn this Account, we summarize the development of a new strategy for streamlined synthesis of tetrahydropyran-embedded macrolactones and its successful implementation to a 13-step synthesis of (–)-exiguolide and an 11-step synthesis of (+)-neopeltolide.1 Introduction2 Development of Macrocyclization/Transannular Pyran Cyclization Strategy3 Total Synthesis of (–)-Exiguolide4 Total Synthesis of (+)-Neopeltolide5 Conclusions
Funder
Japan Society for the Promotion of Science
Chuo University