Affiliation:
1. Division of Performance and Health (Sports Medicine), TU Dortmund
University, Institute for Sport and Sport Science, Dortmund,
Germany
2. Department for Molecular and Cellular Sports Medicine, Institute of
Cardiovascular Research and Sports Medicine, German Sport University Cologne,
Cologne, Germany
Abstract
AbstractAcute exercise induces changes within the T-cell compartment, especially in
cytotoxic CD8+ memory subsets, depending on exercise
intensity and duration. It is unclear whether exercise-induced changes in major
T-cell subsets differ in response to acute high-intensity interval training
(HIIT) or moderate-intensity continuous training (MICT) and whether sex-specific
effects exist. Twenty-four recreationally active runners (females: n=12,
27.8±4.1years,
54.4±4.6 ml*kg-1*min-1;
males: n=12, 31.6±3.8years,
58.9±7.7 ml*kg-1*min-1)
participated in this randomized controlled crossover study, and conducted an
energy- and duration-matched HIIT and MICT session. Blood was sampled before
(T1), immediately (T2) and 1 h after exercise
(T3). Flow cytometry was used to identify T-cell populations.
HIIT decreased the proportion of CD8+ T-cells more
pronounced at T3 compared to MICT (p=0.007), induced a
significantly stronger increase in the CD8+ effector
memory (TEM) cell proportion at T2 (p=0.032), and
decreased CD4+ central memory proportion more
pronounced at T2 (p=0.029). A decrease below baseline
CD8+ TEM proportion at T3
was observed only after HIIT (p<0.001). No interaction effects between
sexes were revealed. Taken together, HIIT represents a more potent stimulus to
induce shifts mainly within the cytotoxic CD8+ T-cell
compartment, thereby giving implications to investigate the role of HIIT on the
cell´s effector phenotype and function in more detail.
Subject
Orthopedics and Sports Medicine,Physical Therapy, Sports Therapy and Rehabilitation