Affiliation:
1. Medicinal Chemistry Laboratory, Department of Chemistry, Meerut
College, Meerut, Uttar Pradesh, India
Abstract
AbstractReaction of piperazine with chloroacetylchloride in dry acetone yield
compound 1 , which on reaction with hydrazine hydrate yielded
compound 2, which was further reacted with various substituted
phenylisothiocyanates in absolute alcohol to afford compounds
3–8 i. e.
2-(carbazolylacetyl)-N-(substitutedphenyl)-hydrazinepiperazinothioamides.
Compounds 3–8 on reaction with aqueous NaOH, ethanolic NaOH
and conc. H2SO4 afford triazoles 9–14,
oxadiazoles 15–20 and thiadiazoles 21–26
respectively. Twenty four newly synthesized compounds were evaluated for
their anticonvulsant activity and acute toxicity. The structures of these
compounds were established on the basis of analytical and spectral data.
Subject
Drug Discovery,General Medicine
Cited by
1 articles.
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