Author:
Qin Hua-Li,Tao Xiang-Feng
Abstract
AbstractA general protocol for the simple, efficient, and mild synthesis of α,β-unsaturated γ-amino sulfonyl fluorides is developed via a base-catalyzed N-alkylation reaction of aromatic amines with (E)-3-bromoprop-1-ene-1-sulfonyl fluoride. This transformation exhibits excellent chemo- and stereoselectivity, mild conditions, broad functional group compatibility and operational simplicity, making it a potentially valuable procedure in medicinal chemistry, chemical biology, and drug discovery.
Funder
National Natural Science Foundation of China
Wuhan University of Technology
Subject
Organic Chemistry,Catalysis