Abstract
AbstractA convenient protocol for the synthesis of A-ring lactones derived from cholesterol was developed. A lactone reduction–lactol separation–reoxidation sequence, applied to the inseparable mixture of diastereomeric lactones, allows the production of multigram amounts of each lactone in pure form. The same sequence applied to A-ring lactones derived from diosgenin produced similar results. A detailed NMR characterization of all the obtained lactones is also provided. X-ray diffraction corroborated the structure of the obtained compounds.
Funder
Consejo Nacional de Ciencia y Tecnología
Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
Universidad Nacional Autónoma de México