Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022) – Part 2 with Recommendations on the Therapy of Precancerous Lesions and Early-stage Endometrial Cancer, Surgical Therapy, Radiotherapy and Drug-based Therapy, Follow-up Care, Recurrence and Metastases, Psycho-oncological Care, Palliative Care, Patient Education, and Rehabilitative and Physiotherapeutic Care-Reference-Cited by-同舟云学术

Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022) – Part 2 with Recommendations on the Therapy of Precancerous Lesions and Early-stage Endometrial Cancer, Surgical Therapy, Radiotherapy and Drug-based Therapy, Follow-up Care, Recurrence and Metastases, Psycho-oncological Care, Palliative Care, Patient Education, and Rehabilitative and Physiotherapeutic Care

Published:2023-08 Issue:08 Volume:83 Page:963-995
ISSN:0016-5751
Container-title:Geburtshilfe und Frauenheilkunde
language:de
Short-container-title:Geburtshilfe Frauenheilkd

Author:

Emons Günter¹,Steiner Eric²,Vordermark Dirk³,Uleer Christoph⁴,Paradies Kerstin⁵,Tempfer Clemens⁶,Aretz Stefan⁷,Cremer Wolfgang⁸,Hanf Volker⁹,Mallmann Peter¹⁰,Ortmann Olaf¹¹,Römer Thomas¹²,Schmutzler Rita K.¹³,Horn Lars-Christian¹⁴,Kommoss Stefan¹⁵,Lax Sigurd¹⁶,Schmoeckel Elisa¹⁷,Mokry Theresa¹⁸,Grab Dieter¹⁹,Reinhardt Michael²⁰,Steinke-Lange Verena²¹²²,Brucker Sara Y.¹⁵,Kiesel Ludwig²³,Witteler Ralf²³,Fleisch Markus C.²⁴,Friedrich Michael²⁵,Höcht Stefan²⁶,Lichtenegger Werner²⁷,Mueller Michael²⁸,Runnebaum Ingo²⁹,Feyer Petra³⁰,Hagen Volker³¹,Juhasz-Böss Ingolf³²,Letsch Anne³³,Niehoff Peter³⁴,Zeimet Alain Gustave³⁵,Battista Marco Johannes³⁶,Petru Edgar³⁷,Widhalm Simone³⁸,van Oorschot Birgitt³⁹,Panke Joan Elisabeth⁴⁰,Weis Joachim⁴¹,Dauelsberg Timm⁴²,Haase Heidemarie⁴³,Beckmann Matthias W.⁴⁴,Jud Sebastian⁴⁵,Wight Edward⁴⁶,Prott Franz-Josef⁴⁷,Micke Oliver⁴⁸,Bader Werner⁴⁹,Reents Nicola³⁸,Henscher Ulla⁵⁰,Schallenberg Miriam⁴³,Rahner Nils⁵¹,Mayr Doris⁵²,Kreißl Michael⁵³,Lindel Katja⁵⁴,Mustea Alexander⁵⁵,Strnad Vratislav⁵⁶,Goerling Ute⁵⁷,Bauerschmitz Gerd J.¹,Langrehr Jan⁵⁸,Neulen Joseph⁵⁹,Ulrich Uwe Andreas⁶⁰,Nothacker Monika J.⁶¹,Blödt Susanne⁶¹,Follmann Markus⁶²,Langer Thomas⁶²,Wenzel Gregor⁶²,Weber Sylvia¹,Erdogan Saskia¹, ,

Affiliation:

1. Universitätsmedizin Göttingen, Klinik für Gynäkologie und Geburtshilfe, Göttingen, Germany

2. Frauenklinik GPR Klinikum Rüsselsheim am Main, Rüsselsheim, Germany

3. Universität Halle (Saale), Radiotherapie, Halle (Saale), Germany

4. Facharzt für Frauenheilkunde und Geburtshilfe, Hildesheim, Germany

5. Konferenz onkologischer Kranken- und Kinderkrankenpfleger (KOK), Hamburg, Germany

6. Frauenklinik der Ruhr-Universität Bochum, Bochum/Herne, Germany

7. Institut für Humangenetik, Universität Bonn, Zentrum für erbliche Tumorerkrankungen, Bonn, Germany

8. Praxis für Frauenheilkunde Hamburg, Hamburg, Germany

9. Frauenklinik Nathanstift – Klinikum Fürth, Fürth, Germany

10. Uniklinik Köln, Frauenheilkunde, Köln, Germany

11. Universität Regensburg, Fakultät für Medizin, Klinik für Frauenheilkunde und Geburtshilfe, Regensburg, Germany

12. Evangelisches Klinikum Köln Weyertal, Gynäkologie Köln, Köln, Germany

13. Universitätsklinikum Köln, Zentrum Familiärer Brust- und Eierstockkrebs, Köln, Germany

14. Universitätsklinikum Leipzig, Institut für Pathologie, Leipzig, Germany

15. Universitätsklinikum Tübingen, Universitätsfrauenklinik Tübingen, Tübingen, Germany

16. Institut für Pathologie, LKH Graz Süd-West, Graz, Austria

17. Pathologisches Institut der LMU München, München, Germany

18. Universitätsklinikum Heidelberg, Diagnostische und Interventionelle Radiologie, Heidelberg, Germany

19. Universitätsklinikum Ulm, Frauenheilkunde und Geburtshilfe, Ulm, Germany

20. Klinik für Nuklearmedizin, Pius Hospital Oldenburg, Oldenburg, Germany

21. MGZ – Medizinisch Genetisches Zentrum München, München, Germany

22. Medizinische Klinik und Poliklinik IV, LMU München, München, Germany

23. Universitätsklinikum Münster, Frauenklinik A Schweitzer Campus 1, Münster, Germany

24. Helios, Universitätsklinikum Wuppertal, Landesfrauenklinik, Wuppertal, Germany

25. Helios Klinikum Krefeld, Klinik für Frauenheilkunde und Geburtshilfe, Krefeld, Germany

26. XCare, Praxis für Strahlentherapie Saarlouis, Saarlouis, Germany

27. Universitätsmedizin Berlin, Frauenklinik Charité, Campus Virchow-Klinikum, Berlin, Germany

28. Universitätsklinik für Frauenheilkunde, Inselspital Bern, Bern, Switzerland

29. Universitätsklinikum Jena, Frauenklinik, Jena, Germany

30. Vivantes Klinikum Neukölln, Klinik für Strahlentherapie und Radioonkologie, Berlin, Germany

31. Klinik für Innere Medizin II, St.-Johannes-Hospital Dortmund, Dortmund, Germany

32. Universitätsklinikum Freiburg, Gynäkologie Freiburg, Freiburg, Germany

33. Universitätsklinikum Schleswig Holstein, Campus Kiel, Innere Medizin, Kiel, Germany

34. Strahlenklinik, Sana Klinikum Offenbach, Offenbach, Germany

35. Medizinische Universität Innsbruck, Universitätsklinik für Gynäkologie und Geburtshilfe, Innsbruck, Austria

36. Universitätsmedizin Mainz, Poliklinik für Geburtshilfe und Frauengesundheit, Mainz, Germany

37. Med. Univ. Graz, Frauenheilkunde, Graz, Austria

38. Semi-Colon, Mönchengladbach, Germany

39. Universitätsklinikum Würzburg, Interdisziplinäres Zentrum Palliativmedizin, Würzburg, Germany

40. Medizinischer Dienst des Spitzenverbandes Bund der Krankenkassen e. V. Essen, Essen, Germany

41. Albert-Ludwigs-Universität Freiburg, Medizinische Fakultät, Tumorzentrum Freiburg – CCCF, Freiburg, Germany

42. Universitätsklinikum Freiburg, Klinik für Onkologische Rehabilitation, Freiburg, Germany

43. Frauenselbsthilfe, Bonn, Germany

44. Universitätsklinikum Erlangen, Frauenklinik, Erlangen, Germany

45. Mutterhaus der Borromäerinnen, Trier, Germany

46. Frauenklinik des Universitätsspitals Basel, Basel, Switzerland

47. Facharzt für Radiologie und Strahlentherapie, Wiesbaden, Wiesbaden, Germany

48. Franziskus Hospital Bielefeld, Klinik für Strahlentherapie und Radioonkologie, Bielefeld, Germany

49. Klinikum Bielefeld Mitte, Zentrum für Frauenheilkunde, Bielefeld, Germany

50. Physio-Akademie, Hannover, Germany

51. Amedes Group Bonn, Bonn, Germany

52. LMU München, Pathologisches Institut, München, Germany

53. Universität Magdeburg, Medizinische Fakultät, Universitätsklinik für Radiologie und Nuklearmedizin, Germany

54. Städtisches Klinikum Karlsruhe, Karlsruhe, Germany

55. Universitätsklinikum Bonn, Zentrum Gynäkologie und gynäkologische Onkologie, Bonn, Germany

56. Universitätsklinikum Erlangen, Brustzentrum Franken, Erlangen, Germany

57. Universitätsmedizin Berlin, Campus Charité Mitte, Charité Comprehensive Cancer Center, Berlin, Germany

58. Martin-Luther-Krankenhaus, Klinik für Allgemein-, Gefäß- und Viszeralchirurgie, Berlin, Germany

59. Uniklinik RWTH Aachen, Klinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, Aachen, Germany

60. Martin-Luther-Krankenhaus, Johannesstift Diakonie, Gynäkologie, Berlin, Germany

61. AWMF, AWMF-IMWi, Berlin, Germany

62. Deutsche Krebsgesellschaft, Office des Leitlinienprogramms Onkologie, Berlin, Germany

Abstract

Abstract Summary The S3-guideline on endometrial cancer, first published in April 2018, was reviewed in its entirety between April 2020 and January 2022 and updated. The review was carried out at the request of German Cancer Aid as part of the Oncology Guidelines Program and the lead coordinators were the German Society for Gynecology and Obstetrics (DGGG), the Gynecology Oncology Working Group (AGO) of the German Cancer Society (DKG) and the German Cancer Aid (DKH). The guideline update was based on a systematic search and assessment of the literature published between 2016 and 2020. All statements, recommendations and background texts were reviewed and either confirmed or amended. New statements and recommendations were included where necessary. Aim The use of evidence-based risk-adapted therapies to treat low-risk women with endometrial cancer prevents unnecessarily radical surgery and avoids non-beneficial adjuvant radiation therapy and/or chemotherapy. For women with endometrial cancer and a high risk of recurrence, the guideline defines the optimum level of radical surgery and indicates whether chemotherapy and/or adjuvant radiation therapy is necessary. This should improve the survival rates and quality of life of these patients. The S3-guideline on endometrial cancer and the quality indicators based on the guideline aim to provide the basis for the work of certified gynecological cancer centers. Methods The guideline was first compiled in 2018 in accordance with the requirements for S3-level guidelines and was updated in 2022. The update included an adaptation of the source guidelines identified using the German Instrument for Methodological Guideline Appraisal (DELBI). The update also used evidence reviews which were created based on selected literature obtained from systematic searches in selected literature databases using the PICO process. The Clinical Guidelines Service Group was tasked with carrying out a systematic search and assessment of the literature. Their results were used by interdisciplinary working groups as a basis for developing suggestions for recommendations and statements which were then modified during structured online consensus conferences and/or additionally amended online using the DELPHI process to achieve a consensus. Recommendations Part 2 of this short version of the guideline provides recommendations on the treatment of precancerous lesions and early-stage endometrial cancer, surgical treatment, radiotherapy and drug-based therapy, follow-up, recurrence, and metastasis of endometrial cancer as well as the state of psycho-oncological care, palliative care, patient education, rehabilitative and physiotherapeutic care.

Publisher

Georg Thieme Verlag KG

Subject

Maternity and Midwifery,Obstetrics and Gynecology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2066-2068.pdf

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