Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2020 – WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS

Author:

Dietrich Christoph F.12,Nolsøe Christian Pállson3,Barr Richard G.4,Berzigotti Annalisa5,Burns Peter N6,Cantisani Vito7,Chammas Maria Cristina8,Chaubal Nitin9,Choi Byung Ihn10,Clevert Dirk-André11,Cui Xinwu12,Dong Yi13,D’Onofrio Mirko14,Fowlkes J. Brian15,Gilja Odd Helge16,Huang Pintong17,Ignee Andre18,Jenssen Christian19,Kono Yuko20,Kudo Masatoshi21,Lassau Nathalie22,Lee Won Jae23,Lee Jae Young24,Liang Ping25,Lim Adrian26,Lyshchik Andrej27,Meloni Maria Franca28,Correas Jean Michel29,Minami Yasunori21,Moriyasu Fuminori30,Nicolau Carlos31,Piscaglia Fabio32,Saftoiu Adrian33,Sidhu Paul S.34,Sporea Ioan35,Torzilli Guido36,Xie Xiaoyan37,Zheng Rongqin38

Affiliation:

1. Department Allgemeine Innere Medizin (DAIM), Kliniken Hirslanden Beau Site, Salem und Permanence, Bern, Switzerland

2. Johann Wolfgang Goethe Universitätsklinik Frankfurt, Germany

3. Center for Surgical Ultrasound, Dep of Surgery, Zealand University Hospital, Køge. Copenhagen Academy for Medical Education and Simulation (CAMES). University of Copenhagen, Denmark

4. Department of Radiology, Northeastern Ohio Medical University, Rootstown, Ohio, USA and Southwoods Imaging, Youngstown, Ohio, USA

5. Hepatology, University Clinic for Visceral Surgery and Medicine, DBMR, Inselspital, University of Bern, Switzerland

6. Dept Medical Biophysics, University of Toronto, Imaging Research, Sunnybrook Research Institute, Toronto

7. Uos Ecografia Internistico-chirurgica, Dipartimento di Scienze Radiologiche, Oncologiche, Anatomo-Patologiche, Policlinico Umberto I, Univ. Sapienza, Rome, Italy

8. Institute of Radiology, Hospital das Clínicas, School of Medicine, University of São Paulo, Brazil

9. Thane Ultrasound Centre, Jaslok Hospital and Research Centre, Mumbai, India

10. Department of Radiology, Chung-Ang University Hospital, Seoul, Korea

11. Interdisciplinary Ultrasound-Center, Department of Radiology, University of Munich-Grosshadern Campus, Munich, Germany

12. Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan China

13. Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China

14. Department of Radiology, G.B. Rossi University Hospital, University of Verona, Verona, Italy

15. Basic Radiological Sciences Division, Department of Radiology, University of Michigan Health System, Ann Arbor, MI, United States

16. National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, and Department of Clinical Medicine, University of Bergen, Norway

17. Department of Ultrasound in Medicine, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

18. Department of Internal Medicine 2, Caritas Krankenhaus, Bad Mergentheim, Germany

19. Krankenhaus Märkisch Oderland, Department of Internal Medicine, Strausberg/Wriezen, Germany

20. Departments of Medicine and Radiology, University of California, San Diego, USA

21. Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan

22. Imaging Department. Gustave Roussy and BIOMAPS. Université Paris-Saclay, Villejuif, France

23. Department of Radiology and Center For Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Departments of Health and Science and Technology and Medical Device Management and Research, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Korea

24. Department of Radiology, Seoul National University College of Medicine, Seoul, Korea

25. Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China

26. Department of Imaging, Imperial College London and Healthcare NHS Trust, Charing Cross Hospital Campus, London United Kingdom

27. Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, United States

28. Radiology Dept, University of Pavia, Milano, Italy

29. Service de Radiologie Adultes, Hôpital Necker, Université Paris Descartes, Paris, France

30. Center for Cancer Ablation Therapy, Sanno Hospital, International University of Health and Welfare, Tokyo, Japan

31. Radiology Department, Hospital Clinic. University of Barcelona, Barcelona, Spain

32. Unit of Internal Medicine, Dept of Medical and Surgical Sciences, University of Bologna S. Orsola-Malpighi Hospital, Bologna, Italy

33. Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy Craiova, Romania

34. Department of Radiology, King’s College Hospital, King’s College London, London

35. Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania

36. Department of Surgery, Division of Hepatobiliary & General Surgery, Humanitas University & Research Hospital, Rozzano, Milano, Italy

37. Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

38. Department of Ultrasound, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Abstract

AbstractThe present, updated document describes the fourth iteration of recommendations for the hepatic use of contrast enhanced ultrasound (CEUS), first initiated in 2004 by the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB). The previous updated editions of the guidelines reflected changes in the available contrast agents and updated the guidelines not only for hepatic but also for non-hepatic applications.The 2012 guideline requires updating as previously the differences of the contrast agents were not precisely described and the differences in contrast phases as well as handling were not clearly indicated. In addition, more evidence has been published for all contrast agents. The update also reflects the most recent developments in contrast agents, including the United States Food and Drug Administration (FDA) approval as well as the extensive Asian experience, to produce a truly international perspective.These guidelines and recommendations provide general advice on the use of ultrasound contrast agents (UCA) and are intended to create standard protocols for the use and administration of UCA in liver applications on an international basis to improve the management of patients.

Publisher

Georg Thieme Verlag KG

Subject

Radiology Nuclear Medicine and imaging

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