Author:
Budynina Ekaterina M.,Ivanov Konstantin L.,Melnikov Mikhail Ya.
Abstract
AbstractAn efficient gram-scale one-pot approach to 2-substituted malonates and related structures is developed, starting from commercially available aldehydes and active methylene compounds. The technique combines Knoevenagel condensation with the reduction of the C=C bond in the resulting activated alkenes with the Zn–AcOH system. The relative ease with which the C=C bond reduction occurs can be traced to the accepting abilities of the substituents in the intermediate arylidene malonates.
Funder
Russian Foundation for Basic Research
Subject
Organic Chemistry,Catalysis
Cited by
4 articles.
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